银耳孢糖对荷瘤小鼠环磷酰胺化疗的增效作用  

Synergistic Effect of Tremella Fuciformis Spores Polysaccharides on Tumor Bearing Mice Treated by Cyclophosphamide

作　　者：徐华丽[1] 于晓风[1] 曲绍春[1] 王迎庆[1] 睢大员[1] 

机构地区：[1]吉林大学药学院药理教研室,长春130021

出　　处：《中国药师》2008年第5期493-495,共3页China Pharmacist

基　　金：吉林省科技发展计划重点项目(20010443)

摘　　要：目的:研究银耳孢糖(Tremella fuciformis spores polysaccharide,TSP)对环磷酰胺(CTX)化疗H_(22)及S_(180)荷瘤小鼠的增效作用。方法:建立小鼠肝癌H_(22)及小鼠肉瘤S_(180)的体内移植性肿瘤模型,随机分为对照组,TSP小、中、大剂量组,CTX小、大剂量组,TSP(小、中、大剂量)+CTX小剂量组,TSP(小、中、大剂量)+CTX大剂量组等12组,接种肿瘤次日开始每天分别腹腔给予0.9%氯化钠注射液、TSP(25,50及100 mg·kg^(-1))、CTX(10,20 mg·kg^(-1))、TSP(25,50,100 mg·kg^(-1))+CTX 10 mg·kg^(-1)及TSP(25,50及100 mg·kg^(-1))+CTX 20 mg·kg^(-1),连续12～14 d,称小鼠的瘤重,测定TSP对CTX的增效作用,每批实验重复3次。结果:TSP 25,50,100 mg·kg^(-1)可明显增加CTX(10,20 mg·kg^(-1))对H_(22)及S_(180)荷瘤小鼠的抑制作用,抑瘤率分别提高6.82～92.01%,3.90～24.27%(P<0.05,0.01);9.50～87.04%,2.41～21.51%(P<0.05,0.01)。结论:TSP与CTX合用对抑制荷瘤小鼠H_(22)及S_(180)有明显的增效作用。Objective： To observe the synergistic effect of Tremella fuciformis spores polysaccharides （TSP） in combination with cyclophospharmide（CTX） on transplanated tumor hepatoma-22 and sarcoma 180 in mice. Method： The transplanted tumor models with hepatoma-22 and Sarcoma 180 were established and then randomized into nine groups, including control group, TSP low, middle and high dose group, CTX low group, CTX high group, TSP （ low, middle and high dose） combined with CTX low groups, TSP （ low, middle and high dose） combined with high groups. The nine groups were injected intraperitoneal with same amount of normal saline, CTX 10,20 mg·kg^-1 ,TSP （25,50,100 mg·kg^-1 ） ＋ CTX 10 mg·kg^-1, TSP （25,50,100 mg·kg^-1） ＋ CTX 20 mg·kg^-1 respectively, once a day for 12 - 14 d. After that, killed them and studied the tumor weight of inhibiting rates. All experiments repeated three times. Result： The tumor weight of inhibiting rates were higher in each TSP plus CTX group than that in CTX groups （ P 〈 0.05 ）. Conclusion： TSP can enhance the anti - tumor efficacy of CTX chemotherapy. They should be studied and exploited furtherly.

关 键 词：银耳孢糖 环磷酰胺 肿瘤 增效 

分 类 号：R285.5[医药卫生—中药学] R979.1[医药卫生—中医学]