服用“纯中药”制剂的癫痫患者抗癫痫药血药浓度监测  

Monitoring of Antiepileptic Western Drugs in Blood of Epileptic Patients Receiving So-called Antiepileptic"Pure Chinese Traditional Medicine"Preparations

作　　者：王锦秋[1] 梁维薇[1] 丰艳梅[1] 

机构地区：[1]西安交通大学医学院第二附属医院药剂科,西安710004

出　　处：《中国药师》2008年第5期521-523,共3页China Pharmacist

基　　金：陕西省科学技术研究发展计划项目[编号:2006k14-G5(3)]

摘　　要：目的:了解某些抗癫痫"纯中药"制剂中是否含有抗癫痫西药成分,为临床合理用药提供依据。方法:对服用"纯中药"制剂的30例癫痫患者,用荧光偏振免疫法(FPIA)筛检其是否含有丙戊酸(VPA)、卡马西平(CBZ)、苯巴比妥(PB)、苯妥英钠(DPA)等4种常用抗癫痫西药。结果:30例患者中,检测出上述1～4种常用抗癫痫西药的28例,占93.3%。其中VPA 16例,平均浓度(12.02±14.97)μg·ml^(-1);CBZ 20例,平均浓度(2.43±2.54)μg·ml^(-1);PB 23例,平均浓度(14.57±16.63)μg·ml^(-1);DPA 22例,平均浓度(7.31±13.43)μg·ml^(-1)。结论:在所谓的抗癫痫"纯中药"制剂中暗加西药较普遍,严重侵犯了患者知情权,妨碍了抗癫痫的正规治疗,有损患者健康。Objective： To understand and prove whether some antiepileptic ＂pure Chinese Traditional medicine＂ preparations containing antiepileptic western drug ingredients in order to provide a theory and experimental basis for clinical drug-use safely and reasonable. Method： The Thirty cases with epileptics, who had took the antiepileptic ＂pure Chinese medicine＂ preparations were monitored for blood concentrations of VPA, CBZ, PB and DPA by FPIA. Result： Thirty patients with epilepsy taken ＂pure Chinese Traditional medicine＂, preparations were examined and one to four kinds of antiepileptic drugs were found in their serum for 28 patients （93.3%）. Patients containing VPA, CBZ, PB, DPA were 16, 20, 23 and 22 respectively. The average blood concentration of VPA, CBZ, PB, DPA were （ 12.02 ± 14.97 ） μm·ml^-1, （ 2.43 ± 2. 54 ） μm·ml^-1 , （ 14.57 ± 16.63 ） μm·ml^-1 and （ 7.31 ± 13.43 ） μm·ml^-1 , respectively. Conclusion： It is ,very common that antiepileptic western drugs were added in ＂pure Chinese Traditional medicine＂ preparations, which violates the patients with standard therapy and does harm to their health.

关 键 词：中药 抗癫痫药 血药浓度监测 

分 类 号：R97[医药卫生—药品]