生物组织光传播的时域特征分析  

Time Domain Characteristics of Light Propagation in Tissue

作　　者：应金品[1,2] 包正康[1,2] 陆祖康 

机构地区：[1]浙江大学物理系 [2]浙江大学现代光学仪器国家重点实验室

出　　处：《光学学报》1997年第12期1671-1676,共6页Acta Optica Sinica

基　　金：现代光学仪器国家重点实验室开放课题

摘　　要：采用蒙特卡罗（Ｍｏｎｔｅ－Ｃａｒｌｅ）方法对脉冲光在组织中传播的时域特征作了研究，并把计算结果与漫射理论的解析解作了比较。文中详细分析了组织光学特性参数与组织表面时间分辨的漫反射光分布之间的关系。结果表明：散射系数影响着漫反射光强到达峰值的时间，吸收系数影响着漫反射光强在峰值之后随时间下降的速度，而ｇ因子对响应曲线的前沿影响较大，在后沿阶段基本上没有影响。文中的另一个结论是从时间分辨的漫反射光测量中可以无损地反演组织的光学特性参数，从而可以以一种更迅速、方便的方式无损地测量组织中血氧和肌氧的含量。The time resolved Monte Carlo method is used to study the time domain characteristics of light pulse propagation in tissue. The simulation results of Monte Carlo method are compared with the analytic results of diffuse theory. The relation between the optical parameters of tissue and the time resolved reflectance on tissue surface is discussed. The results illustrate that the time of maximum reflectance is mainly affected by the scattering coefficient, the slope of the reflectance decrease is mainly affected by the absorption coefficient. The g factor only affects the early data of the time resolved reflectance. The results in this paper show more promise to apply in the noninvasive measurement of the optical parameters of tissue and the oxygen saturation in arterial and skeletal muscle.

关 键 词：光传播 吸收 散射 时域特征 脉冲光 生物组织 

分 类 号：Q63[生物学—生物物理学]