知母宁清除活性氧作用的研究  

STUDIES OF SCAVENGING EFFECTS ON ACTIVE OXYGENS OF CHINONIN

作　　者：张红雨[1,2] 王芙媛[1,2] 李明[1,2] 张志义 李美芬[1,2] 

机构地区：[1]中国科学院生物物理所 [2]深圳银湖南方制药厂三九药业医药研究院生化室

出　　处：《辐射研究与辐射工艺学报》1997年第4期224-228,共5页Journal of Radiation Research and Radiation Processing

摘　　要：用ＥＳＲ及自旋捕捉技术研究了知母宁（从中药知母中提取的有四个酚羟基的口山酮化合物）在均相和非均相体系中对·ＯＨ、Ｏ·－２和１Ｏ２等几种活性氧的清除、猝灭效果。发现知母宁对·ＯＨ、１Ｏ２均有较强的清除和猝灭作用，效果好于维生素Ｅ，并通过动力学方法求得其在均相体系中对１Ｏ２的猝灭速率常数为７．２×１０８ｍｏｌ－１Ｌｓ－１。Chinonin, a kind of xanthonoid compound with four phenolic hydroxyls, is extracted from Anemarrhena asphodeloides Bunge, a sort of traditional Chinese medicine In this paper, ESR and spin trapping techniques are used to study its scavenging effects on ·OH, O2·-  and 1O2 in homogeneous and heterogeneous system It is found that chinonin possesses fairly strong scavenging activity on ·OH and 1O2, which is better than that of V E Through kinetic method, quenching rate constant of chinonin on 1O2 is determined as 72× 108mol-1L s-1

关 键 词：知母宁 活性氧 ESR 自旋捕捉 氧自由基清除 

分 类 号：R977.9[医药卫生—药品] R96[医药卫生—药学]