广谱抗病毒抗生素17997体内外抗病毒活性研究  

Antiviral study on the broad spectrum antiviral antibiotic 17997 in vitro and in vivo

作　　者：陶佩珍[1] 娄志贤[1] 姚天爵[1] 张兴权[1] 线素文 姚恩泰[1] 刘玉珍[1] 王淑琴[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所

出　　处：《中国抗生素杂志》1997年第5期368-372,391,共6页Chinese Journal of Antibiotics

基　　金：国家自然科学基金

摘　　要：从我国云南省土壤中分离到１株放线菌，其产生的抗生素１７９９７具有广谱抗病毒作用。在细胞培养内对单纯疱疹病毒１型、单纯疱疹病毒２型、人免疫缺陷病毒１型、水疱性口炎病毒及柯萨奇病毒Ｂ３均有显著抑制活性，ＩＣ５０在μｍｏｌ／Ｌ水平。其在小鼠体内对单纯疱疹病毒１型及２型所致疱疹性脑炎有确切治疗效果，对死亡保护率及平均生存日与对照组相比有统计意义的显著差别。In our regular screening program using herpes simplex virus type 1 as target, a broad spectrum antiviral antibiotic produced by a Streptomyces has been found. The antiviral activities of antibiotic 17997 have been inves tigated in vitro and in vivo. In cell culture, antibiotic 17997 shows strong inhibition against herpes simplex virus type 1 (HSV 1), type 2 (HSV 2), human immunodeficiency virus type 1 (HIV 1), vesicular stomatitis virus (VSV) and coxsackie virus B3 (Cox B3) with IC 50 values in μmol/L level. In vivo studies antibiotic 17997 was effective in treatment of HSV 1 and HSV 2 systematic mouse infections. Antibiotic 17997 reduced the mortality of infected mice and extended the average survival days of infected mice with statistical significance. Mice were tolerated well with all dosages.

关 键 词：抗病毒抗生素 抗生素 17997 抗病毒活性 

分 类 号：R978.1[医药卫生—药品] R978.7[医药卫生—药学]