Enhanced efficiency of generating induced pluripotent stem （iPS） cells from human somatic cells by a combination of six transcription factors  

作　　者：Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao 

机构地区：[1]Laboratory of Molecular Cell Biology, Key Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Cell Bank, Stem Cell bank, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

出　　处：《Cell Research》2008年第5期600-603,共4页细胞研究（英文版）

基　　金：Acknowledgment This research was supported by grants from the Ministry of Science and Technology of China （2006CB943901, 2007CB948003）; the National Natural Science Foundation of China （30600306, 30623003）; Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences （2007KIP 101,2007KIP401）, Chinese Academy of Sciences.

摘　　要：Dear Editor, Human embryonic stem （ES） cells possess the potential to differentiate into all the cell types of the human body and provide potential applications in regenerative medicine . However, the concerns of immune rejection hamper transplantation therapies using human ES cells. To avoid the complications of immune rejection, diverse methods, such as somatic nuclear transfer （also called therapeutic cloning） and fusion of somatic ceils with human ES ceils , have been attempted to produce patient-specific pluripotent stem cells. Most of these approaches have resulted in little success. The generation of human iPS cells （induced

关 键 词：胚胎干细胞 体细胞 再生医学 转录因子 

分 类 号：Q2[生物学—细胞生物学]