商陆皂甙甲对人外周血单核细胞产生肿瘤坏死因子的抑制作用  

Inhibitory effect of esculentoside A on TNF production by human monocytes

作　　者：郑钦岳[1] 方军[1] 王洪斌 

机构地区：[1]第二军医大学药学院药理学教研室

出　　处：《第二军医大学学报》1997年第5期415-417,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：研究商陆皂甙甲（ＥｓＡ）对脂多糖（ＬＰＳ）刺激人外周血单核细胞产生肿瘤坏死因子（ＴＮＦ）的影响。方法：用Ｌ９２９细胞作靶细胞的生物测定法，检测与ＥｓＡ共育的受ＬＰＳ刺激的人外周血单核细胞上清中ＴＮＦ的含量。结果：当ＥｓＡ浓度在１和１０μｍｏｌ／Ｌ时，受ＬＰＳ刺激的人单核细胞产生ＴＮＦ显著减少。结论：减少ＴＮＦ的释放可能是ＥｓＡ的抗炎作用机制之一。Objective: To study how EsA affects the production of TNF by human monocytes stimulated by LPS. Methods: determining the TNF level of supernatant of human peripheral monocytes incubated with LPS and EsA by bio assay. Results: Decrease of TNF production by human monocytes induced by LPS was striking at the concentration of EsA arranged from 1 to 10 μmol/L. Conclusion: Decrease of TNF releasing might be one of the mechanisms of anti inflammation of EsA.

关 键 词：商陆皂甙甲 肿瘤坏死因子 单核细胞 抗炎作用 

分 类 号：R282.710.7[医药卫生—中药学]