血压波动性增高引起的器官损伤  

Significant organs damage induced by high blood pressure variability in SAD rats

作　　者：龚侃[1,2,3] 刘建国[1,2,3] 程勇[1,2,3] 刘建华 朱铨英 苏定冯[1,2,3] 

机构地区：[1]第二军医大学基础医学部药理学教研室 [2]济南军区青岛第一疗养院 [3]中国科学院上海药物研究所

出　　处：《第二军医大学学报》1997年第5期462-464,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：研究去窦弓神经（ＳＡＤ）大鼠的血压、血压波动性（ＢＰＶ）和器官损伤及它们之间的相互关系。方法：应用计算机化清醒自由活动大鼠血流动力学监测技术对３２周龄的ＳＡＤ大鼠进行２４ｈ动态血压监测。数据经计算机实时和脱机分析后得到２４ｈ血压、收缩压波动性（ＳＢＰＶ）、舒张压波动性（ＤＢＰＶ）等参数。将动物处死，取心脏、肾脏、大脑等器官病理切片，分别行一般和特殊染色。参照预先制定的评分标准，根据所观察器官大体和镜下变化，给每一只动物以相应的评分作为器官损伤程度的半量化指标。将血压及ＢＰＶ与器官损伤评分做相关性分析。结果和结论：（１）ＳＡＤ大鼠的２４ｈ长、短期及总ＳＢＰＶ和ＤＢＰＶ明显高于假手术对照组；（２）ＳＡＤ大鼠的器官损伤明显重于假手术对照组，并且这种损伤与其长期ＢＰＶ和总ＢＰＶ的提高有正相关性。Objective: To study the relationship between blood pressure (BP), blood pressure variability (BPV) and organs damage in SAD rats at 32 weeks of age. Methods: Intra arterial blood pressure was continuously recorded for 24 h in freely moving SAD rats by micro computer system. On line and off line computer analysis of the BP curve allowed calculation of BP and BPV. Hearts, kidneys,brains and spleens were excised, fixed, dehydrated and embeded in paraffin. Sections were stained with HE and special methods separately to assess the severity of organs damage. Organs damage was semiquantified according to predetermined criteria. Results and Conclusion:(1)24 h long term , short term and total SBPV and DBPV were higher in SAD rats than those in control rats [SBPV: (1.2±0.5),(1.5±0.5), (1.9±0.5) vs (0.7±0.2), (1.2±0.2), (1.4±0.2) kPa,P<0.01;DBPV: (0.9±0.3), (1.5±0.3), (1.8±0.3) vs (0.7±0.5), (1.3±0.2), (1.6±0.2)kPa, P<0.01)]. (2) Organs damage scores were higher in SAD rats than those in control rats [(7.6±2.44 )vs (3.6±1.59),P<0.001] and organs damage was positively correlated with 24 h long term and total BPV in SAD rats.

关 键 词：血压 血压波动性 器官损伤 动态监测 

分 类 号：R590.2[医药卫生—内科学] R443.5[医药卫生—临床医学]