窄谱中波紫外线预照射对自体表皮移植治疗稳定期白癜风的疗效影响  

The effect of NB-UVB on stable vitiligo accompanied with autologous epidermis grafting

作　　者：陈惠英[1] 樊齐敏[1] 郑冬娣[1] 许爱娥[1] 

机构地区：[1]杭州市第三人民医院皮肤科,杭州310009

出　　处：《中华物理医学与康复杂志》2008年第4期257-259,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的观察窄谱中波紫外线（NB-UVB）预照射对稳定期白癜风自体表皮移植疗效的影响。方法将82例稳定期白癜风患者随机分为治疗组与对照组，治疗组患者白斑处首先进行8次以上NB-UVB照射，然后行自体表皮移植治疗；对照组单纯行自体表皮移植治疗。跟踪随访3个月观察疗效。结果NB-UVB照射可明显提高自体表皮移植患者皮片的存活和复色率，疗效明显优于对照组（P〈0．05）；治疗组散在性白癜风的痊愈率明显高于对照组（P〈0．05）；疗效与照射次数、移植部位、色素出现时间等有关。结论NB-UVB预照射可明显提高稳定期白癜风自体表皮移植的疗效。Objective To observe the curative effect of narrow-band ultraviolet （NB-UVB） on stable vitiligo with autologous epidermis grafting. Methods A total of 82 patients with stable vitiligo were recruited and randomly divided into a control group and a treatment group. The patients in the treatment group were pretreated with NB-UVB before autologous epidermis grafting, while those in the control group were not. The pretreatment with NB-UVB was implemented twice a week for at least 4 weeks before the autologous epidermis grafting. A 3-month follow-up observation was conducted with regard to the effectiveness. Results Pretreatment with NB-UVB could significantly increase the survival rate of skin grafts and rate of repigment of leukoplakia, when compared with autologous epidermises transplantation alone. The rate of complete repigment raised significantly （ P 〈 0.05 ）, and so did the curative effect for vulgaris generalized vitiligo （ P 〈 0. 029）. It was found that the curative effect on vitiligo was closely related to the frequency of NB-UVB radiation,location of leukoplakia,color of skin, and the time of repigment appearance. Conclusion Pretreatment with NB-UVB can significantly improve curative effect of autologous epidermis grafting on vitiligo.

关 键 词：白癜风 紫外线 窄波 移植 表皮 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]