含芳基四唑的糖氨基噁二唑/噻二唑衍生物的合成  

Synthesis of Glycosylamino-oxadiazole/thiadiazole Derivatives Containing Aryltetrazole

作　　者：郭中献[1] 曹玲华[1] 

机构地区：[1]新疆大学化学化工学院,新疆乌鲁木齐830046

出　　处：《新疆大学学报（自然科学版）》2008年第2期131-136,共6页Journal of Xinjiang University(Natural Science Edition)

基　　金：国家自然科学基金20462006资助项目

摘　　要：以S-(1-芳基-1H-四唑-5-基)巯乙酰肼(1a～1c)和糖基异硫氰酸酯(2a,2b)为原料,高产率地合成了新的N-糖基-2-[S-(1-芳基-1H-四唑-5-基)巯乙酰氨基]硫脲3a～3f,然后分别在醋酸汞/乙醇体系或乙酸酐/磷酸体系中合环,得到一系列新的2-(1-芳基-1H-四唑-5-硫亚甲基)-5-糖氨基噁二唑/噻二唑化合物4a～4f,5a～5f.目标化合物的结构均经IR,1HNMR及元素分析确证.A series of new N -glycosyl-2-[ S -（ 1-aryl- 1H -tetrazol-5-yl） mercaptoacetamido]thioureas 3a - 3f have been synthesized in high yields from S-（1-aryl-1 H-tetrazol-5-yl） mercaptoacetohydrazine （1a -1c） and glycosyl isothiocyanates （2a, 2b）, then 3a - 3f were converted to a series of new 2-（1-aryl- 1H- tetrazol-5- ylthiomethylene）-5-glycosylamino-oxadiazoles/thiadiazoles 4a-4f, and 5a- 5f respectively under mercuric acetate/alcohol system or acetic anhydride/phosphoric acid system. All the target compounds were characterized by IR, ^1H NMR and elemental analysis.

关 键 词：四唑 糖基异硫氰酸酯 噁二唑 噻二唑 

分 类 号：O622[理学—有机化学]