反映胰岛素抵抗的最佳血脂指标研究  

Study on Optimal Index of Serum Lipids for Predicting Insulin Resistance

作　　者：马玉琢[1] 李明辉[2] 马占姝[3] 

机构地区：[1]赤峰市医院内分泌科,内蒙古赤峰024000 [2]赤峰学院附属医院泌尿外科,内蒙古赤峰024000 [3]赤峰学院附属医院CT-MRI室,内蒙古赤峰024000

出　　处：《内蒙古医学杂志》2008年第4期417-418,共2页Inner Mongolia Medical Journal

摘　　要：目的:探讨反映胰岛素抵抗(IR)的最佳血脂指标。方法:采用赤峰市医院体检中心健康体检资料,2006年10月体检中无糖尿病史且空腹血糖<5.6 mmol/L的人群2 010例参加此项研究,根据甘油三酯(TG)按百分位数法将研究对象均等地分为3组,以稳态模式法的胰岛素抵抗指数(HOMA-IR)评价IR。结果:HOMA-IR随TG升高而增加,各组间差异有显著性意义(P均<0.01);以HOMA-IR为因变量的多元逐步回归分析显示血脂指标中仅TG进入回归方程;TG对IR诊断的敏感性和特异性优于高密度脂蛋白胆固醇、总胆固醇、低密度脂蛋白胆固醇。结论:TG是反映IR的最佳血脂指标。Objective：To investigate the optimal index of blood lipids for predicting insulin resistance（IR）.Methods：2010 cases with fasting blood sugar less than 5.6 mmol/L and without history of diabetic mellitum were recruitted on Oct 2006.The cases were divided into 3 groups based on TG by method of percentiles.The level of IR was evaluated by the homeostasis model assessment insulin resistance index（HOMA-IR）.Results：HOMA-IR increased by TG,the differences among groups was significant（P〈0.01）.The results of multivariate stepwise regression analysis showed TG is the isolated index of blood lipids associated with HOMA-IR.The sensitivity and specificity of TG in diagnosis of IR was superior to that of high-dense lipoprotein cholesterol,total cholesterol and low-dense lipoprotein cholesterol.Conclusion：TG is the optimal index of serum lipids for predicting IR.

关 键 词：甘油三酯 胰岛素抵抗 ROC曲线 

分 类 号：R589.2[医药卫生—内分泌]