TPSA FPSA及FPSA/TPSA在前列腺疾病诊断中的临床意义  

The Clinical Significance of TPSA、FPSA and FPSA/TPSA Detection in diagnosis of prostate disease

作　　者：刘杰[1] 刘增[1] 刘文豹[1] 

机构地区：[1]内蒙古医学院第三附属医院核医学科,内蒙古包头014010

出　　处：《内蒙古医学杂志》2008年第4期428-430,共3页Inner Mongolia Medical Journal

摘　　要：目的:探讨血清总的前列腺特异抗原(TPSA)、游离前列腺特异抗原(FPSA)及FPSA/TPSA检测在前列腺良性疾病与前列腺癌诊断中的意义。方法:应用电化学发光分析法检测正常对照组(58例)、前列腺炎组(69例)、前列腺增生症组(104例)及前列腺癌组(39例)血清TPSA、FPSA含量及FPSA/TPSA比值。结果:正常对照组血清TPSA、FPSA含量及FPSA/TPSA比值分别为1.63±0.79、0.32±0.21、0.26±0.19;前列腺炎组血清TPSA、FPSA含量及FPSA/TPSA比值分别为3.01±2.77、0.65±0.28、0.31±0.24;前列腺增生症组血清TPSA、FPSA含量及FPSA/TPSA比值分别为6.97±4.14、1.56±1.10、0.37±0.21,前列腺癌组血清TPSA、FPSA含量及FPSA/TPSA比值分别为52.29±24.36、9.17±8.32、0.12±0.10。前列腺炎组与正常对照和前列腺增生组比较差异无显著性(P>0.05),前列腺增生组与正常对照组比较差异有显著性(P<0.01),前列腺癌组TPSA、FPSA与其他3组比较差异均有显著性(P<0.01),前列腺癌组FPSA/TPSA明显降低,与其他3组比较差异均有显著性(P<0.05)。结论:检测TPSA、FPSA含量及FP-SA/TPSA是提高前列腺疾病诊断与鉴别诊断有效的方法,尤其对前列腺癌诊断更有临床意义。Objective：To explore the diagnostic value of detecting total prostate-specific antigen（TPSA）、free prostate-specific antigen（FPSA）and FPSA/TPSA ratio in benign prostate disease and prostate cancer.Methods：TPSA、FPSA and FPSA/TPSA were detected in control group（58 patients）、prostatitis group（69 patients）、benign prostatic hyperplasia group（104 patients）and prostate cancer group（39 patients）using electrochemiluminescence analysis.Results：The serum contents of TPSA、FPSA and FPSA/TPSA ratio were 1.63±0.79、0.32±0.21、0.26±0.19 in control group;the serum contents of TPSA、FPSA and FPSA/TPSA ratio were 3.01±2.77、0.65±0.28、0.31±0.24 in prostatitis group;the serum contents of TPSA、FPSA and FPSA/TPSA ratio were 6.97±4.14、1.56±1.10、0.37±0.21 in benign prostatic hyperplasia group;the serum contents of TPSA、FPSA and FPSA/TPSA ratio were 52.29±24.36、9.17±8.32、0.12±0.10 in prostate cancer group.There was no significant difference between prostatitis group and control group、benign prostatic hyperplasia group（P〉0.05）;there was significant difference between benign prostatic hyperplasia group and control group（P〈0.01）;the contents of TPSA、FPSA in prostate cancer group had significant difference compared with other groups（P〈0.01）,the FPSA/TPSA ratio was significantly lower than other groups（P〈0.05）.Conclusion：It was a effective method to improve diagnosis and differential diagnosis of prostate disease through detecting TPSA、FPSA and FPSA/TPSA,especially in diagnosis of prostate cancer.

关 键 词：前列腺 TPSA FPSA FPSA/TPSA 

分 类 号：R697.3[医药卫生—泌尿科学]