多器官功能障碍综合征患者血浆内毒素水平与预后的关系  

Relationship Between Endotoxin and Prognosis of Multiple Organ Dysfunction Syndrome

作　　者：张会云[1] 张磊[1] 王勇强[1] 曹书华[1] 

机构地区：[1]天津第一中心医院ICU,天津300192

出　　处：《中华医院感染学杂志》2008年第5期653-655,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨血浆内毒素水平在判断多器官功能障碍综合征(MODS)患者预后的意义。方法回顾性分析60例MODS患者,存活组23例,死亡组37例,对比两组患者于入院第1、3、5、7天血浆内毒素的水平,并分析入院第1天不同内毒素的水平与预后的关系。结果死亡组患者入院第1、3、5、7天血浆内毒素水平均高于存活组患者(P<0.05);以入院第1天内毒素水平判断MODS患者预后,以血浆内毒素水平2003.8 pg/ml作为截断点,其判断患者预后不良的特异度达87.0%,阳性预测值达90.6%。结论血浆内毒素水平可作为判断MODS患者预后的指标。OBJECTIVE To explore the effect of plasma endotoxin on the prognosis of multiple organ dysfunction syndrome （MODS）. METHODS Retrospective analysis was carried out on 60 patients of MODS. They were 23 patients in survival group and 37 patients in death group, compared the level of plasma endotoxin on the dd 1, 3, 5, and 7 after admitted in both groups, and analyzed the relationship between the plasma endotoxin and lethal outcome. RESULTS The level of plasma endotoxin in death group was higher than that of survival group on the dd 1, 3, 5, and 7 （P〈0. 05）. The level of plasma endotoxin on the first day decided the prognosis of MODS patients,when the cutoff point was 2003. 8pg/ml, the specificity was 87% and the positive predicted value was 90.6%. CONCLUSIONS The level of plasma endotoxin can be a prognostic factor for MODS patients.

关 键 词：多器官功能障碍综合征 内毒素 预后 

分 类 号：R181.32[医药卫生—流行病学]