临床分离铜绿假单胞菌对5种β-内酰胺类抗菌药物的耐药性分析  

Resistance of Pseudomonas aeruginosa Strains to Five β-Lactams

作　　者：陈国胜[1] 熊自忠[1] 魏艳艳[1] 

机构地区：[1]安徽医科大学第一附属医院感染病科,安徽合肥230022

出　　处：《中华医院感染学杂志》2008年第5期704-705,共2页Chinese Journal of Nosocomiology

基　　金：安徽省自然科学基金资助项目(050430804)

摘　　要：目的了解临床分离铜绿假单胞菌对5种临床常用β-内酰胺类抗菌药物的耐药性,以指导临床用药。方法琼脂稀释法检测2005年分离自安徽省不同地区的218株铜绿假单胞菌对头孢曲松、头孢噻肟、氨曲南、头孢他啶、哌拉西林的耐药性。结果铜绿假单胞菌对头孢曲松、头孢噻肟、氨曲南、哌拉西林、头孢他啶的耐药率分别为59.2%、57.3%、56.0%、51.8%、39.0%;头孢曲松、头孢噻肟、氨曲南、哌拉西林耐药率之间差异无统计学意义(P>0.05),但它们与头孢他啶耐药率差异有统计学意义(P<0.01);其中分离自合肥地区的73株铜绿假单胞菌的耐药率与全省平均水平差异无统计学意义(P>0.05)。结论临床分离铜绿假单胞菌对头孢曲松、头孢噻肟、氨曲南、哌拉西林耐药显著,对头孢他啶较为敏感。OBJECTIVE To investigate the resistance of Pseudomonas aeruginosa strains to 5 β-1actams. METHODS Susceptibility of 218 P. aeruginosa strains isolated from Anhui Province in 2005 to ceftriaxone, cefotaxime, ceftazidime, aztreonam, and piperacillin were tested by agar dilution method. RESULTS The resistance rate to ceftriaxone, cefotaxime, aztreonam, piperacillin, and ceftazidime were 59. 2%, 57.3%, 56.0%, 51. 8%, and 39. 0%, respectively. There was statistically significant difference between ceftazidime and other 4 β-1actams （P〈0. 01）. The resistance rate of 73 is P. aeruginosa strains isolated from the city of Hefei was not drastically higher than that of the total Anhui Province （P〉0.05）. CONCLUSIONS Ceftazidime is the most susceptible antibiotic to P. aeruginosa strains among 5 β-1actams tested.

关 键 词：铜绿假单胞菌 耐药性 抗菌药物 

分 类 号：R978.1[医药卫生—药品]