近红外光谱无创血糖测量的极限检测浓度  

Detection limit of glucose concentration in noninvasive sensing with near infrared spectroscopy

作　　者：罗云瀚[1] 陈哲[1] 陈星旦[1] 

机构地区：[1]暨南大学理工学院光电工程系应用光谱实验室,广东广州510632

出　　处：《光学精密工程》2008年第5期784-788,共5页Optics and Precision Engineering

基　　金：国家自然科学基金资助项目(No.10076009);广东省自然科学基金资助项目(No.7300084)

摘　　要：通过分析血糖浓度变化对光学参数的两种作用及其对光传播的影响,针对葡萄糖主要分布于皮肤真皮层的特点,引入了有效信噪比的概念,推导出血糖检测极限浓度与光源检测器之间距离和有效仪器信噪比之间的关系。针对不同个体表皮和真皮厚度的差异,用蒙特卡洛方法研究了其对检测极限浓度的影响,讨论了光学测头设计的方案和适应性。结果表明,通过选择合适的光源与检测器之间距离,来自真皮层的有效信号能超过50%;假定仪器信噪比为10 000,可获得满足FDA要求的血糖检测极限浓度。By analyzing two kinds of influence of the variation of glucose concentration on optical properties and its light propagation effect, the relationship among detection limit of glucose concentration, source-detector separation and the signal-to-noise ratio of measurment system is derived. According to different thicknesses of epidermis and dermis,their effects on detection limit of glucose concentation are researched with Monte Carlo method. The research results show that the effective photons from dermis layer can be more than 50% by selecting optimal source-detector separation, and the require ment of FDA for noninvasive glucose sensing can be satisfied when supposing the instrument SNR is 10 000.

关 键 词：血糖浓度测量 无创测量 近红外光谱 检测极限 

分 类 号：O657.33[理学—分析化学] R446.1[理学—化学]