冠心病患者11-DH-TXB_2水平分析及其与预后的关系  

The analysis of 11-DH-TXB2 level and its proghosis value in patients with coronary heart disease

作　　者：王志军[1] 苏永臣[2] 温建艳[3] 柯元南[3] 

机构地区：[1]华北煤炭医学院附属医院,河北唐山063000 [2]武警唐山市消防支队新华医院 [3]卫生部中日友好医院

出　　处：《山东医药》2008年第14期25-27,共3页Shandong Medical Journal

基　　金：河北省科技厅科技攻关课题(06-2761904)。

摘　　要：目的探讨冠心病患者血浆11-脱氢-血栓素B2(11-DH-TXB2)水平变化及其与预后的关系。方法203例住院患者应用酶联免疫法测定血浆中11-DH-TXB2水平,记录心血管疾病危险因素、伴随临床疾病、超声心动图、冠状动脉造影结果及介入治疗措施等。记录随访1 a时心血管病事件。结果冠心病患者11-DH-TXB2水平高于对照组。11-DH-TXB2水平与冠心病严重程度及严重病变支数相关。11-DH-TXB2水平增高与随访1 a发生心血管病事件相关。结论冠心病患者11-DH-TXB2水平升高能够反映病情的严重性,预示患者发生心血管事件的危险性增加。Objective To analyz 11-dehydro-thromboxane B2 （ 11-DH-TXB2 ） level and it＇ s prognostic value in patients with coronary heart disease （CHD）. Methods 203 consecutive hospitalized patients were enrolled. Enzyme linked immunosorbent assay was used to detect the serum levels of 11-DH-TXB2. Recorded blood biochemical indicator, concomitance risk factors and diseases, ultrasonic echocardiogram, coronary arteriongraphy results, interventional therapy were recorded. One-year follow-up recurrent cardiovascular （CV） events were recorded. Results The 11-DH-TXB2 level of CHD patients was higher than that of normal groups obviously and correlated with lesion severity, the number of impaired coro- nary arteries, female and diabetes. Increased 11-DH-TXB2 level correlated with the risk of one-year follow-up recurrent CV events. Conclusion Increased 11-DH-TXB2 level of CHD patients correlates with severe affection and worse prognosis of one-year follow-up.

关 键 词：冠状动脉疾病 11-脱氢-血栓素B2 预后 心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]