靶向超声微泡构建的策略和选择  

Strategies and Choices of Construction of Targeted Ultrasound Microbubbles

作　　者：陈少敏[1] 宾建平[1] 

机构地区：[1]南方医科大学南方医院心内科,广东广州510515

出　　处：《心血管病学进展》2008年第3期393-396,共4页Advances in Cardiovascular Diseases

基　　金：国家"863"计划项目(2006AA02Z478)

摘　　要：利用超声微泡表面固有的生物学特性或通过特殊处理将特定配体连接于超声微泡表面可构建成靶向超声微泡,靶向超声微泡经静脉注入后能靶向性聚集并较长时间滞留于靶组织或靶器官中,并通过对比超声产生分子水平成像。实验研究表明靶向对比超声技术可无创性的定量评价诸如血管内皮损伤/炎症、血栓形成、肿瘤血管新生等病变组织和器官。靶向超声微泡的构建作为靶向对比超声技术的核心和关键近年来的研究进展十分迅速。By virtue of inherent biological characteristics of the surface of ultrasound microbubbles,or connecting specific ligand to the surface of ultrasound microbubbles through special treatment, targeted ultrasound microbubbles can be constructed. Via intravenous injection, the targeted ultrasound microbubbles can gather at the target tissue or target organ and remain there for a long time, so molecular imaging can be produced by contrast-enhanced ultrasound. Experimental studies have shown that targeted contrast-enhanced ultrasound can evaluate the lesions of the target tissues and organs, such as vascular endothelial injury/inflammation, thrombosis and tumour angiogenesis in quantitative and non-invasive manner. Studies in the construction of targeted ultrasound microbubbles,which is the key part of targeted contrast-enhanced ultrasound technology, have evolved rapidly in recent years.

关 键 词：微泡 靶向 对比超声 构建 

分 类 号：R445.1[医药卫生—影像医学与核医学]