超声微泡携带基因治疗血管再狭窄的研究进展  

Advances in Gene Therapy Mediated by Ultrasound Microbubbles for Vascular Restenosis

作　　者：王沛[1] 张平洋[1] 

机构地区：[1]南京医科大学附属南京第一医院心血管超声科,江苏南京210006

出　　处：《心血管病学进展》2008年第3期396-400,共5页Advances in Cardiovascular Diseases

摘　　要：血管成形术后的再狭窄是当前介入治疗面对的一大难题。分子生物学技术的发展提供了许多可用于治疗血管再狭窄的基因,然而由于缺乏安全高效的转运方法,基因治疗的实际应用受到了很大的限制。现将介绍超声微泡介导基因转运技术,并讨论利用该技术进行血管再狭窄基因治疗的离体和在体实验进展,以及今后的发展方向和应用前景。Vascular restenosis after angioplasty is a serious clinical problem. The advances in molecular biology provides many new targets for specific gene therapy to prevent vascular restenosis, However, successful gene therapy remains an elusive and challenging goal for the lack of an effective and safe delivery system. In this review, we will introduce a novel gene vector, the ultrasound microbubble, discuss its mechanism,and review the research progress in vitro and in vivo,including the promising application in the therapy against vascular restenosis.

关 键 词：再狭窄 微泡 基因治疗 超声波 

分 类 号：R543[医药卫生—心血管疾病]