阿司匹林抵抗与基因多态性  

Aspirin Resistance and Genetic Polymorphisms

作　　者：吴镜[1] 徐俊波[1] 段潇潇 

机构地区：[1]成都市第三人民医院,四川成都610031 [2]绵阳市长虹医院,四川绵阳600000

出　　处：《心血管病学进展》2008年第3期451-455,共5页Advances in Cardiovascular Diseases

摘　　要：阿司匹林具有抗血小板聚集的作用,用于心肌梗死和缺血性脑血管病的预防。但在长期随访中发现,应用阿司匹林治疗的冠心病病人仍有可能发生缺血性血管事件,也就是存在阿司匹林抵抗现象。虽然其发生机制尚不明确,但基因多态性与阿司匹林抵抗的发生有一定的关系。现就近年来关于阿司匹林抵抗与基因多态性关系的一些研究结果。Aspirin is an effective anti-platelet agent, and is widely used for the prophylaxis of cardiovascular events in patients with cardiovascular risk factors or established atherosclerotic disease. However, despite aspirin treatment, a substantial number of patients experience recurrent events. Such ＇ aspirin resistance＇ is generally defined as failure of aspirin to produce an expected biological response. Whilst its aetiology is multifactorial, genetic factors are also likely to play their part. Here we review the evidence for and against such a genetic contribution,as well as the data suggesting the involvement of specific genes.

关 键 词：阿司匹林抵抗 基因多态性 

分 类 号：R971[医药卫生—药品]