中药金果榄两种基源植物的化学成分(英文)  

Chemical Constituents of Two Original Plants Used as Radix Tinosporae

作　　者：史琪荣[1] 沈云亨[1] 张川 柳润辉[1] 张卫东[1] 

机构地区：[1]第二军医大学药学院天然药物化学教研室,上海200433

出　　处：《中国天然药物》2008年第3期186-190,共5页

摘　　要：目的:研究中药金果榄(Radix Tinosporae)两种基源植物:青牛胆(Tinospora sagittata)和金果榄(Tinospora capillipes)的化学成分,并比较它们物质基础的差别,为中药多基源植物的应用提供证据。方法:青牛胆和金果榄的根分别用95%的乙醇回流提取,在真空下浓缩提供乙醇提取物。乙醇提取物分别用氯仿和正丁醇萃取。氯仿部位和正丁醇部位分别用硅胶、Sephadex LH-20、重结晶技术及反相HPLC半制备液相分离纯化,所得化合物通过它们的波谱数据并与文献值比较进行鉴定。结果:从青牛胆从分离鉴定了12个化合物(1-12)。另外从金果榄中分离鉴定了11个与青牛胆中化合物相同的结构(1-11)。结论:中药金果榄两种基源植物具有类似的化学物质基础。其中化合物1-3及7-9为首次从金果榄中分离得到。AIM： To study the chemical constituents of two original plants used as TCM Radix Tinosporae, and compare the material foundation of two original plants of Radix Tinosporae. METHODS： The roots of Tinospora sagittara and T. capillipes were refluxed with 95% EtOH, respectively, and the extracts were concentrated to afford ethanol extracts, which were partitioned with CHCl3 and n-Butanol. The fractions obtained were submitted to column chromatography over silica gel, Sephadex LH-20, and purified by RP-HPLC on a C18 μ-Bondapak column （7. 8 mm×30 cm, flow rate 2.0 mL·min^-1） with 30% MeOH and recrystallization （ MeOH）. The compounds were identified on the basis of their spectroscopic data. RESULTS： Compounds 1-12 were isolated from Tinospora sagittata, and the identical compounds 1-11 from Tinospora capillipes. CONCLUSIONS： Two original plants of TCM Radix Tinosporae have the same effective material foundation based on the similarity of chemical constituents of these two plants. Compounds 1-3 and 7- 9 were isolated from T. capillipes for the first time.

关 键 词：青牛胆 金果榄 防已科 化学成分 基源植物 

分 类 号：R284[医药卫生—中药学]