混合皮肤移植诱导的免疫耐受  

Immunotolerance following intermingled skin transplantation

作　　者：高成金[1] 郇京宁[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院烧伤整形科,上海市200025

出　　处：《中国组织工程研究与临床康复》2008年第18期3532-3536,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：应用计算机检索PubMed数据库与维普数据库有关混合皮肤移植的文章,资料显示,皮肤表皮层主要由角质形成细胞和少量树突状细胞组成,因此研究皮肤混合移植有必要研究异基因角质形成细胞的嵌合和异基因树突状细胞的嵌合。目前在混合皮肤移植领域还没有关于树突状细胞嵌合的深入研究。关于皮肤微嵌合的研究仅局限在外源性干细胞移植诱导供、受者嵌合致免疫耐受,在异体皮肤移植和和混合皮肤移植中并未发现供、受者间的微嵌合现象。调节性T细胞、Th3细胞、NKT细胞在诱导混合皮肤移植免疫耐受现象中也发挥着重要作用。PUBMED Database and Vip Database were undertaken to identify relevant articles on intermingled skin transplantation. Skin cuticular layer consists of keratinocytes and dendritic cells （DCs）, so the researches on intermingled skin transplantation includes the chimerism of allo-keratinocyte and the chimerism of allo-DCs. There is no study about the chimerism of allo-DCs at present. The investigations on skin microchimerism are limited to the immunotolerance induced by exogenous stem cell transplantation, and the microchimerism phenomenon has not been found in allo-skin transplantation and intermingled skin transplantation. Regulating T cells, Th3 cells and NKT cells play important roles in the induction of the immunotolerance after intermingled skin transplantation.

关 键 词：混合 皮肤 移植 干细胞 免疫耐受 

分 类 号：R318.08[医药卫生—生物医学工程]