Graves病患者泪膜功能研究  

The study of tear film function in Graves disease

作　　者：谢怀林[1] 林育华[1] 王善洁[1] 蒋艳华[1] 曾少杰[1] 李慧娟[2] 

机构地区：[1]广西壮族自治区南溪山医院眼科,桂林541002 [2]广西壮族自治区南溪山医院内分泌科,桂林541002

出　　处：《中国医师进修杂志》2008年第5期10-12,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨Graves病患者的泪膜功能。方法前瞻性研究78例Graves病患者（病例组），对照组为40例健康体检者。分别进行泪膜破裂时间测定（TBUT）、基础泪液分泌试验（SIT）、角膜荧光素染色和眼部干涩、不适症状询问。结果病例组TBUT和SIT与对照组比较，差异均有统计学意义（P〈0．05）。TBUT〈10S和自觉有眼干涩症状以及角膜荧光素染色阳性的比率，病例组与对照组比较，差异均有统计学意义。结论Graves病患者发生泪膜功能异常的比率高于健康体检者，是发生干眼症的易患人群。Objective To investigate the tear film function with Graves disease. Methods Seventy-eight patients with Graves disease were studied respectively, 40 cases healthy person as control. Tear film function was evaluated by tear break-up time （TBUT）, Schirmer I test （SIT）, corneal fluorescein staining, dry eye and unwell symptoms. Results The difference of TBUT and SIT results between patients and controls were significant （P 〈 0.05）. The rate of TBUT, corneal fluorescein staining and symptom of dry eye in patients were significantly higher than those in controls. Conclusions Graves disease patients have higher rate of abnormal tear film function in comparison with controls. Graves disease are correlated with xerophthalmia.

关 键 词：格雷夫斯病 干眼病 泪膜功能 

分 类 号：R581.1[医药卫生—内分泌] R587.1[医药卫生—内科学]