复方丹参滴丸对人肝脏药物代谢酶CYP1A2活性的影响  

Effect of Compound Danshen Dripping Pills on Cytochrome CYP1A2 Activity

作　　者：吴慧[1] 陈作忠[2] 彭向前[3] 张鉴[4] 

机构地区：[1]淄博矿业集团有限责任公司中心医院,淄博市255120 [2]淄博市中心医院,淄博市255031 [3]聊城大学生命科学学院,聊城市252059 [4]山东省立医院,济南市250021

出　　处：《中国药房》2008年第15期1182-1184,共3页China Pharmacy

摘　　要：目的:研究复方丹参滴丸对人肝脏药物代谢酶CYP1A2活性的影响,指导临床合理用药。方法:采用反相高效液相色谱法测定服用复方丹参滴丸前、后人尿液内咖啡因4种主要代谢产物的相对含量;采用(AFMU+1X+1U)/17U比率法评价人肝脏药物代谢酶CYP1A2活性的变化。结果:受试者用药前CYP1A2的平均活性为4·20±1·54,服用复方丹参滴丸14d后CYP1A2的平均活性为4·26±1·95,用药28d后CYP1A2的平均活性为4·35±1·26,二者分别比用药前升高1·42%和3·57%,但无统计学差异。结论:服用治疗剂量的复方丹参滴丸对人肝脏药物代谢酶CYP1A2的活性无明显影响,不会影响与之合用的需经CYP1A2代谢药物的疗效。OBJECTIVE： To investigate the effect of Compound danshen dripping pills on cytochrome CYP1A2 activity for reterence of clinical rational drug use. METHODS： The contents of four major metabolites of Caffeine, i.e. 5 acetylamino- 6 formylamino 3- methyluracil（AFMU）, 1 - methylxanthine（1X）, 1 - methyluric acid（1U） and 1, 7- dimethyluricacid （ 17U） in the urine before and after oral administration of Compound danshen dripping pills were determined by RP - HPLC. The activity of cytochrorne CYP1A2 was derived from the ratio of （AFMU ＋ 1X ＋ 1U）/17U. RESULTS： The average activity of CYP1A2 was 4.20± 1.54 before medication, which stood at 4.26± 1.95 at 14 days and 4.35± 1.26 at 28 days after medicauon, up 1.42% and 3.57%, respectively, yet there was no significant difference after medication as compared with before medication. CONCLUSION： No significant difference was noted on CYP1A2 activity after oral medication of Compound danshcn dripping pills, nor does it modify the efficacy of the concurrent drugs that metabolized by CYP1A2.

关 键 词：复方丹参滴丸 人肝脏药物代谢酶CYP1A2 咖啡因代谢物 反相高效液相色谱法 

分 类 号：R283.64[医药卫生—中药学] R975.5[医药卫生—中医学]