HPS病儿急性期血浆IL-13和IL-15水平变化及意义  

THE CHANGES OF PLASMA CONCENTRATION OF IL-13 AND IL-15 IN CHILDREN WITH HENOCH-SCHOENLEIN PURPURA AND THEIR SIGNIFICANCE

作　　者：江忠[1] 田菊[2] 卢云宏[1] 张秋业[2] 

机构地区：[1]青岛大学医学院第二附属医院小儿科,山东青岛266042 [2]青岛大学医学院附属医院小儿内科

出　　处：《齐鲁医学杂志》2008年第2期117-119,共3页Medical Journal of Qilu

摘　　要：目的探讨过敏性紫癜(HSP)病儿急性期血浆白细胞介素13(IL-13)和白细胞介素15(IL-15)水平的变化及其在HSP发病机制中的意义。方法应用双抗体夹心ELISA法,对61例HSP病儿急性期血浆IL-13和IL-15水平进行检测,对不同临床类型HSP间血浆IL-13和IL-15水平进行比较,并以25例健康儿童作为正常对照组。结果HSP病儿急性期血浆IL-13水平显著高于正常对照组(t′=5.49,P<0.01)。有、无肾损害组血浆IL-13水平皆高于正常对照组,差异有显著性(F=53.92,q=13.87、3.40,P<0.01、0.05);有肾损害组显著高于无肾损害组(q=11.86,P<0.01)。HSP病儿急性期血浆IL-15水平亦显著高于正常对照组(t′=8.98,P<0.01);有、无肾损害组血浆IL-15水平均显著高于正常对照组,差异有显著性(F=40.45,q=12.18、3.46,P<0.01);有肾损害组显著高于无肾损害组(q=9.95,P<0.01)。结论HSP病儿急性期血浆IL-13和IL-15水平显著升高在HSP发病机制中有重要作用,而且与紫癜性肾炎的发生、发展关系密切。Objective To investigate the changes of interleukin-13 （IL-13） and interleukin-15 （IL-15） in children with Henoch-Schoenlein purpura （HSP） and discuss the related clinical significance. Methods Plasma levels of IL-13 and IL-15 were detected by ELISA in 61 children with HSP in acute phase and 25 normal children. The level of IL-13 and IL-15 of HSP children in different clinical categories were compared. Results IL-13 level in children with HSP in acute phase was significantly higher than that of healthy controls （t′= -5.49,P〈0.01） ; IL-13 level of HSP children with or without renal involvement was significantly higher than that of healthy controls （F=53.92,q=13.87,3.40;P〈0. 01 or 0. 05）, those with renal involvement was significantly higher than that without renal involvement （F=53.92;q=11.86,P〈0.01）. IL-15 level of children with HSP in acute phase was significantly higher than that of the controls （t′=8. 98,P〈0. 01） ; IL-15 level of children with HSP with or without renal involvement was significantly higher than that of healthy controls （F= 40.45 ; q = 12.18,3.46 ; P〈 0. 01 ） ; and those with renal involve- ment was significantly higher than that without （q=9.95 ,P〈0.01）. level of children with HSP in acute phase suggests that IL-13 and IL-15 nephritis of HSP. Conclusion Significant increase in plasma IL-13 and IL-15 play a crucial role in pathogenesis of HSP and correlate with nephritis of HSP.

关 键 词：紫癜 过敏性 白细胞介素-13 白细胞介索-15 血浆 儿童 

分 类 号：R725.5[医药卫生—儿科]