螺旋CT灌注成像结合动态增强扫描对肺内结节／肿块的诊断价值研究  

The Study of Combination of CT Perfusion and Dynamic Contrast-enhanced CT in the Differential Diagnosis of Pulmonary Nodule or Mass

作　　者：金志发[1] 罗良平[2] 陈金城[2] 邓玉英[2] 李国岱[2] 

机构地区：[1]广东省江门市中心医院(中山大学附属江门医院放射科),529030 [2]暨南大学附属第一医院医学影像中心,广州510630

出　　处：《临床放射学杂志》2008年第5期614-618,共5页Journal of Clinical Radiology

摘　　要：目的探讨螺旋CT灌注成像与常规动态增强扫描在肺内结节或肿块鉴别诊断中的应用价值。资料与方法经病理或临床证实的肺内结节或肿块患者81例,行CT灌注扫描及常规动态增强扫描,计算病灶感兴趣区的血流量(BF)、血容量(BV)、平均通过时间(MTT)和表面渗透性(PS)以及描绘时间-密度曲线(TDC),比较三组结节或肿块之间的区别。结果恶性和活动性炎性结节或肿块的BV及PS值明显高于良性结节(P<0.05)。三组结节或肿块间BF和MTT值无统计学差异。恶性与活动性炎性结节或肿块之间各灌注值有较明显重叠。三组结节或肿块的(TDC)不同。结论螺旋CT灌注成像与常规动态增强扫描结合有利于肺内结节或肿块的鉴别诊断。Objective To evaluate the role of combination of CT perfusion and dynamic contrast - enhanced CT in the differential diagnosis of pulmonary nodule or mass. Materials and Methods Eighty-one patients with pathologically or clinically confirmed pulmonary nodule or mass underwent CT perfusion and dynamic contrast-enhanced CT scanning. The perfusion parameters including blood flow （BF）, blood volume （BV）, mean transmit time （MTT） and permeability surface （PS）, and the time-density curve （TDC）type based on dynamic contrast-enhanced CT in three groups were compared. Results The mean BV and PS of malignant group and active inflammatory group were significantly higher than those of benign group （ P 〈 0.05 ）. There was no significant difference in the mean BF and MTT between three groups. There was no significant difference in the mean BF, BV, MTT, and PS between malignant group and active inflammatory group. The TDC type of three groups was different. Conclusion Combination of CT perfusion and dynamic contrast-enhanced CT could contribute to the differential diagnosis of pulmonary nodule or mass.

关 键 词：肺 结节 灌注 体层摄影术 X线计算机 

分 类 号：R816.4[医药卫生—放射医学]