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作 者:林慧文[1] 缪士霞[1] 高晓波[1] 李小华[2] 吴哲[1]
机构地区:[1]广州市第十二人民医院妇产科,510620 [2]广州市红十字会医院,510220
出 处:《广州医药》2008年第3期30-33,共4页Guangzhou Medical Journal
基 金:广州市医药卫生科技项目(项目编号:2006-YB-120);广东省医学科学技术研究基金项目(项目编号:WSTJJ20061201)
摘 要:目的探讨氧氟沙星联合甲硝唑在子宫颈环形电切术后局部用药的临床应用价值。方法选用因宫颈非恶性病变行子宫颈环形电切术(LEEP)的患者100例,均在术后使用氧氟沙星联合甲硝唑预防感染治疗,将其随机分为两组,即阴道局部用药组(实验组)和口服用药组(对照组)各50例,比较两组的手术时间、术中出血量、术后最高体温和术后住院天数以及术后阴道排液量、阴道出血时间及宫颈创面愈合情况等。结果两组的手术时间、术中出血量、切割的刀数、热凝次数、术后最高体温和术后住院天数无显著性差异(P>0.05)。实验组术后阴道排液量少于月经量的患者较对照组明显减少(P<0.05),阴道出血时间少于5天的患者较对照组明显增加(P<0.05),术后4周、8周和12周宫颈创面的痊愈率明显高于对照组(P<0.01和P<0.05)。结论LEEP术后氧氟沙星联合甲硝唑阴道用药,疗效好,副反应少,是一种安全、方便、有效的方法,值得临床推广。Objective To investigate the effect of collagen and Ofloxacin and flagyl on cervix wound surface after loop electrosurgical excision procedure (LEEP) . Methods One hundred patients undergoing LEEP were randomly divided into two groups (n = 50) . In the study group patients received the treatment on cervix wound surface after LEEP with Ofloxacin and flagyl via the vagin way , and patients were treated with Ofloxacin and flagyl by mouth after LEEP in the control group. Results There were no significat differences in the duration of operation, intraoperative blood loss, the frequences of cut and heat cure, the highest temperature after operation and the length of hospital stay ( P 〉 0, 05) . The numbers of patients whose vagin discharges were less than menstrual blood volume in the study group were less than those in the control group (P 〈 0. 05 ) . The numbers of patients whose vagin bleeding durations were less than 5 days in the study group were more than those in the control group ( P 〈0. 05 ) . The recovery incidences of cervix wound surface 4 weeks, 8 weeks and 12 weeks after operation in the study group were significant higher than those in the control group (P 〈 0. 01 or 0. 05) . Conclusion The treatment on cervix wound surface after LEEP with Ofloxacin and flagyl via the vagin way is a safe, convenient, effective method with less side effects.
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