3-氨基-5-羧基-1，2，4-三唑席夫碱的合成  

Synthesis of 3-amino-5-carboxyl-1,2,4-triazole Schiff bases

作　　者：陈书哲[1] 孙晓红[1] 刘源发[2] 陶燕[1] 陈邦[2] 白燕[1] 

机构地区：[1]西北大学化工学院化学研究所,陕西西安710069 [2]西北大学化学系,陕西西安710069

出　　处：《化学工程》2008年第4期65-67,共3页Chemical Engineering(China)

基　　金：陕西省自然科学基金资助项目(2001H11);西北大学科研启动基金资助项目

摘　　要：含1,2,4-三唑环的席夫碱化合物一般都具有很好的生物活性。为了进一步探讨1,2,4-三唑席夫碱的合成,文中以3-氨基-5-羧基-1,2,4-三唑为原料,与取代芳醛反应,合成了8个3-氨基-5-羧基-1,2,4-三唑类席夫碱化合物。采用的反应条件为:3-氨基-5羧基-1,2,4-三唑与取代芳醛的摩尔比为1∶1,N,N-二甲基甲酰胺(DMF)为溶剂,冰醋酸为催化剂,在回流温度下反应3.5—4.5 h。化合物的结构通过IR,1H NMR和元素分析进行了表征。样品分析结果表明,在红外光谱中,所得目标产物在波数ν=1 600—1 625 cm-1处均出现C N的特征吸收峰;在1H核磁共振中,化学位移δ9附近有CH N的质子的化学位移出现。Schiff bases of 1,2,4-triazole are normally with good biological activity. In order to further discuss their synthesis, eight Schiff bases of 3-amino-5-carboxyl-1,2,4-triazole derivatives were synthesized by condensation of 3-amino-5-carboxyl-1,2,4-triazole with substituted aromatic aldehydes in the presence of glacial acetic acid as catalyst. The reaction was carried in N,N-dimethyl formamide （DMF） under refluxing for 3.5-4.5 h with molar ratio of 3-amino-5-earboxyl-1,2,4-triazole to aromatic aldehyde 1： 1. The structures of the compounds were confirmed by IR, ^1 H NMR and elemental analysis. The results show that all the compounds obtained have the C=N characteristic absorption band at v = 1 600-1 625 cm^-1 in the IR and the proton chemical shift of CH ：N around δ9 in the ^1 H NMR.

关 键 词：三唑 取代芳醛 席夫碱 结构 

分 类 号：TQ252.6[化学工程—有机化工]