慢性乙型肝炎患者肝脏B超形态学、基质金属蛋白酶-2及其组织抑制因子血清水平与肝纤维化分期之间的关系  

Association of B-type ultrasonographic manifestation,serum MMP-2 and TIMP-2 levels with hepatic fibrosis staging in patients with chronic hepatitis B

作　　者：徐乐天[1] 梁琨[1] 

机构地区：[1]中南大学湘雅医院B超室,湖南长沙410008

出　　处：《第四军医大学学报》2008年第10期906-908,共3页Journal of the Fourth Military Medical University

摘　　要：目的:评价慢性乙型肝炎患者肝脏B超形态学改变、血清基质金属蛋白酶-2(MMP-2)及其组织抑制因子(TIMP-2)水平与其肝纤维化程度的关系.方法:对56例慢性乙型肝炎患者行B超引导下肝活检及肝组织纤维化分期;B超检查测定门静脉主干(MPV)、脾静脉(SPV)宽度及脾脏厚度;用ELISA方法检测慢性乙型肝炎患者的血清MMP-2和TIMP-2的含量,并与18例健康人员作对比,分析二者与患者肝纤维化程度之间的关系.结果:慢性乙型肝炎患者的脾脏厚度、门静脉主干及脾静脉宽度随患者肝纤维化分级的增加而增大(P<0.05);血清MMP-2,TIMP-2水平随肝纤维化程度的加重而升高,r分别为0.806,0.712,P均<0.01.结论:肝脏B超形态学改变及血清MMP-2,TIMP-2水平的变化对慢性乙型肝炎患者早期肝纤维化的诊断是具有重要意义的.AIM： To investigate the association of B-type ultrasonographic manifestation of liver, levels of serum matrix metaloproteinase-2 （MMP-2） and tissue inhibitor of metaloprotienase-2 （TIMP-2） with hepatic fibrosis staging in patients with chronic hepatitis B. METHODS： Fifty-six patients with chronic hepatitis B underwent liver biopsy under the conduction of B-type ultrasonography. Width of main portal vein （MPV） and splenic vein （SV）, and thickness of spleen were examined by B-type ultrasonography. Serum levels of MMP-2 and TIMP-2 were measured by ELISA. RESULTS ： The imaging of blood vessels of liver and the thickness of spleen were significantly associated with the degree of liver fibrosis in chronic hepatitis B cases （ P 〈 0. 05 ）. Moreover, the levels of serum MMP-2 and TIMP-2 were dramatically increased following staging of hepatic fibrosis in patients with chronic hepatitis B （P 〈 0. 01 ）. CONCLUSION： B-type ultrasonographic manifestation of liver and levels of serum MMP-2, TIMP-2 play significant roles in diagnosis of early stage hepatic fibrosis.

关 键 词：超声检查 明胶酶A 金属蛋白酶-2组织抑制 肝炎 乙型 慢性 肝硬化 

分 类 号：R512.62[医药卫生—内科学]