新型生物可降解心血管涂层支架的制备及其生物相容性的研究  

A Novel Biodegradable Copolymer for Coronary Artery Stent:Preparation and its Biocompatibility in vivo

作　　者：赵燕超[1] 刘学波[2] 葛均波[2] 龚飞荣[1] 陈功雨[1] 胡源浚[1] 程树军[1] 陈建定[1] 

机构地区：[1]华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室,上海200237 [2]复旦大学附属中山医院上海市心血管病研究所,上海200032

出　　处：《中国生物医学工程学报》2008年第3期438-442,共5页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(30170368);国家863项目(2002AA326110);上海市科委项目(044319213;05DJ14005)

摘　　要：采用共价键连接技术,以二环己基碳化二亚胺(DCC)为偶联剂,将肝素与具有官能侧基的脱保护聚乳酸和吗啉二酮衍生物共聚物材料连接,肝素本体重量含量达到15%。与共混肝素材料的肝素体外释放实验对比结果证明该连接技术对肝素有良好的控制释放效果。并且利用独特的计算机控制喷涂工艺将共聚物的四氢呋喃(THF)溶液喷涂到支架上,制备出了心血管涂层支架,扩张后表面涂层无脱落和撕裂。涂层支架与金属裸支架对比动物实验发现,1、2和3个月的动物实验血管切片显示涂层支架无急性血栓和再狭窄情况的发生。说明该材料具有良好的生物相容性,具有广阔的应用前景。A copolymer of L-lactide and morpholine-2,5-dione derivative was grafted with heparin by covalent binding using N, N＇-dicyclohexyl carbodiimide （DCC） as the coupling reagent. The amount of heparin grafted reached 15 % . The results of heparin release in PBS showed that the modification method could well control the release rate, compared with the copolymer mixed with heparin. The solution of copolymer in tetrahydrofuran（THF） was sprayed onto the stent surface to form a coating. The coating exhibited sufficient flexibility of allowing the stent to expand without cracking or peeling from the stent. The results of in vivo showed that no in-stent thrombosis and restenosis were observed in any stenting groups, indicating good biocompatibility.

关 键 词：肝素化 生物可降解涂层 聚乳酸共聚物 心血管支架 再狭窄 

分 类 号：R318.08[医药卫生—生物医学工程]