开放性伤口感染的病原菌及其耐药性分析  

Analysis of the pathogenic bacteria and their drug resistance during open wound infection

作　　者：陈曼丹[1] 辜红妮[1] 林漫燕[1] 蓝柳燕[1] 邱小华[1] 林广玲[1] 

机构地区：[1]汕头大学医学院附属第二医院检验科,515041

出　　处：《国际检验医学杂志》2008年第5期404-406,共3页International Journal of Laboratory Medicine

摘　　要：目的分析总结医院骨伤和烧伤患者开放性伤口病原菌的分布及耐药状况。方法用VITEK-AMS微生物自动分析仪鉴定菌种和药物试验,对菌种分布特点及耐药性进行分析,同时对大肠埃希菌和肺炎克雷伯菌进行ESBLs检测。结果开放性伤口感染病原菌分离率最高的为铜绿假单胞菌(18.9%),其后依次为大肠埃希菌(13.3%)、凝固酶阴性葡萄球菌(10.1%)、金黄色葡萄球菌(9.5%)、克雷伯菌属(7.2%)和真菌(6.9%)等;大肠埃希菌和肺炎克雷伯菌ESBLs检出率分别为32.5%和6.5%;铜绿假单胞菌对常用抗菌药物已有较高耐药性;大肠埃希菌和肺炎克雷伯菌对亚胺培南100%敏感。结论了解开放性伤口感染病原菌的组成结构及其耐药变化趋势,可加强抗感染治疗的针对性和主动性,为临床取得最佳的感染防治效果提供科学依据。Objective To study the distribution of pathogenic bacteria and their drug resistance during open wound infection in patients with bone trauma and burn injury in the past four years. Methods VITEK-AMS Automatic Microbial Analyzer was employed to identify the species and perform drug susceptibility test, and then the pathogenic bacteria distributed characteristic and drug resistance were analyzed. Meanwhile, ESBLs produced by E. coli and K. pneumoniae were detected. Results The isolated rate of Pseudomonas aeruginosa was the highest （18. 9%） in open wound infection, followed by that of E. coli （13.3%）, coagulase negative staphylococcus （10.1%）, Staphylococcus aureus （9.5%）, K. pneumoniae （7.2%）, and fungi （6.9%）. The detection rate of ESBLs was 32.5 %and 6.5 % for E. coli and K. respectively. Pseudomonas aeruginosa was high resistant to commly-used antibiotics. E. coli and K. pneumoniae were 100% sensitive to imipenem. Conclusion Understanding of the pathogenic bacteria distribution and drug resistance tendency contributes to the enhancement of antibiotical therapy specificity and activity, and providing scientific basis for optimal efficiency of prevention and treantment for infection.

关 键 词：伤口感染 病原 耐药性 细菌 抗菌药物 

分 类 号：R446.5[医药卫生—诊断学]