良性前列腺增生MRS检查尿道周围单体波谱代谢特点研究  

Study on the characters of the unit through urethra in MRS of benign prostatic hyperplasia

作　　者：史志杰[1] 李峰[2] 王守红[3] 曹凤宏[2] 王霄英[4] 赵丽君[3] 李晓强[2] 

机构地区：[1]河北省唐山工人医院分院泌尿外科,河北唐山063000 [2]华北煤炭医学院附属医院泌尿外科,河北唐山063000 [3]华北煤炭医学院附属开滦医院核磁共振室,河北唐山063000 [4]北京大学第一医院医学影像科,北京100034

出　　处：《医学影像学杂志》2008年第4期384-387,共4页Journal of Medical Imaging

基　　金：河北省科学技术研究与发展第二批指导计划项目;课题编号为:062761996

摘　　要：目的:探讨良性前列腺增生MRS检查尿道周围单体与不同病理类型前列腺组织的差异。方法:对16例前列腺增生的患者术前行MRS检查,观察枸橼酸盐(cit)胆碱化合物(cho)和肌酸(cre)波峰,并测定不同单体的(cho+cre)/cit值(包括尿道周围单体)。行耻骨上经膀胱前列腺摘除术后的标本进行大病理切片检查,将波谱图像的(cho+cre)/cit值与前列腺的病理类型分别进行记录。结果:前列腺腺体增生型(cho+cre)/cit值为0.59±0.29;基质增生型(cho+cre)/cit值为1.23±0.38;混合增生型(cho+cre)/cit值为0.80±0.27,尿道周围单体(cho+cre)/cit值为0.68±0.33。经统计处理,尿道周围单体与间质型增生及混合型增生存在统计学差异,与腺体型增生无统计学差异(P<0.05)。结论:尿道周围单体(cho+cre)/cit值主要取决于尿道周围的腺体组织,与腺体型增生组织的(cho+cre)/cit值相近,在前列腺MRS的诊断中具有重要的价值。Objective： To study the characters of the unit through urethra in MILS of benign prostatic hyperplasia and the differences with three pathologic types. Methods：Magnetic resonance spectroscopy appearances were researched in sixteen patients with benign prostatic hyperpLasia, the peaks of citrate, choline and creatine were observed, the ratios of （choline± creatine）/citrate were measured including the unit through urethra. After suprapubic transvesical prostatectomy the specimens were inspected in the method of whole pathologic section. The values of （cho＋ cre）/cit and pathologic types of benign prostatic hyperplasia were recorded correspondingly and handled statistically.ResuRs：The ratios of （choline ± creatine）/citrate of three pathologic types of benign prostatic hyperplas/a and the unit through urethra were 0.59 ± 0.29, 1.23 ± 0.38, 0.80 ± 0.27 and 0.68 ± 0.33 （mean± standard deviation）. There were statistical differences among the unit through urethra, mixed hyperpLasia and interstitial hyperpLasia. There were not statistical difference between the units through urethra and glandular hyperpLasia（ P 〈 0.05）. Conclusion：The ratios of the unit around urethra depended on mainly glandular tissues near urethra. MILS may be useful to clear the characters of the units through urethra.

关 键 词：前列腺增生 磁共振波谱分析 病理类型 尿道周围单体 

分 类 号：R697[医药卫生—泌尿科学] R445.2[医药卫生—外科学]