探讨血清1,5-脱水葡萄糖醇和糖化血清蛋白对妊娠期糖代谢异常的诊断价值  

The diagnostic value of 1,5-Anhydro-D-glucitol and glucosylated serum protein in abnormal glucometabolism in pregnancy

作　　者：陈益川[1] 张德亭[1] 朱勇[2] 张红萍[2] 

机构地区：[1]温州市第三人民医院检验科,浙江温州325000 [2]温州市第三人民医院妇产科,浙江温州325000

出　　处：《检验医学》2008年第3期268-270,共3页Laboratory Medicine

摘　　要：目的探讨糖化血清蛋白(GSP)及1,5-脱水葡萄糖醇(1,5-AG)在妊娠期糖代谢异常诊断中的价值。方法对正常妊娠组、糖筛查异常组及糖耐量异常组进行空腹葡萄糖、口服葡萄糖50g筛选、GSP、1,5-AG测定。结果糖筛查异常组GSP水平为(154±18)μmol/L、糖耐量异常组GSP水平为(157±26)μmol/L,与正常妊娠组[(136±30)μmol/L]比较,差异有统计学意义(P<0.01)。糖筛查异常组和糖耐量异常组1,5-AG水平分别为(57.3±30.2)μmol/L、(45.2±25.7)μmol/L,显著低于正常妊娠组水平[(84.5±35.6)μmol/L,P<0.01]。结论GSP、1,5-AG可作为妊娠期糖代谢异常筛查及诊断指标。Objective To investigate the diagnostic value of glucosylated serum protein（GSP） and 1,5-Anhydro-D- glucitol （1,5-AG） in abnormal glucometabolism in pregnancy. Methods The fasting blood glucose （FBG）, 50 g glucose challenge test（ GCT）, GSP, 1,5-AG in normal pergnancy group, abnormal GCT pergnancy group and abnormal o- ral glucose tolerance test（OGTT） pregnancy group were determined. Results The levels of GSP in abnormal GCT preg-nancy group and abnormal OGTT group were （154±18） μmol/L, （157±26） μmol/L respectively, and they were significantly higher than that in normal pregnancy group （[136±30]μmol/L,P 〈 0.01 ）. The levels of 1,5-AG abnormal GCT pregnancy group and abnormal OGTT group were （57.3±30.2）μmol/L and （45.2±25.7）μmol/L respectively, and they were significantly lower than that in normal pregnancy group （[84.5±35.6 ] μmol/L, P〈0.01 ）. Conclusions GSP and 1,5-AG are indicators for screening and diagnosing pregnant glucometabolism abnormality.

关 键 词：1 5-脱水葡萄糖醇 糖化血清蛋白 糖筛查异常 妊娠 糖耐量异常 

分 类 号：R446.1[医药卫生—诊断学]