胃粘膜肠化与胃癌关系的粘液组织化学研究  

Mucin-histochemical Study on the Relationship Between the Intestinal Metaplasia of Gastric Mucosa and Stomach Carcinoma

作　　者：张亚琳[1] 魏洪臣[1] 田晨光[1] 周英发[1] 

机构地区：[1]河南医科大学第二附属医院,郑州市450003

出　　处：《中国肿瘤临床》1997年第11期838-840,共3页Chinese Journal of Clinical Oncology

摘　　要：本文应用粘液组织化学技术，对117例胄癌、62例慢性胃炎伴（肠化生）组织的粘液分泌进行观察。根据所含粘液不同，将胄癌分为肠型及胃型，将畅化分为大肠型及小肠型。肠型胃癌的肠化检出率显著高于胃型胃癌（P＜0．01）。大肠型肠化在肠型胃癌旁肠化检出率显著高于在胄型胄癌旁肠化及慢性胃炎伴肠化的检出率（P＜0．01）。肠型胃癌的发生与胄粘膜肠化，特别与大肠型肠化关系密切。因此，加强对大肠型肠化的密切随访．有利于胃癌的早期发现。Mucin-histochemical technics were used to analyse the mucin secretion in 117 cases of gastric carcinomas and 62 cases of chronic gastritis accompanied by intestinal metaplasia. According to the difference of the mucin secretion,the gastric carcinomas were divided into intestinal type and gastric type, and, the intestinal metaplasia was divided into large intestinal type and small intestinal type.The result showed that the positive prevalence of intestinal type of gastric carcinomas was significantly higher than that of the gastric type of gastric carcinoma (P<0. 01). Large intestinal type metaplasia was more common in metaplastic mucosa next to intestinal type of gastric carcinoma than that in metaplastic mucosa next to gastric type of gastric carcinoma or in chronic gastritis accompanied by intestinal me-taplasia (P<0.01). The origination of intestinal type of gastric carcinomas is related to the intestinal metaplasia of gastric mucosa, especially to large intestinal type of metaplasia. Follow-up of the patients with large intestinal type of metaplasia will be of value in the discovery of early gastric carcinoma.

关 键 词：胃肿瘤 胃粘膜肠化 粘液组织化学 

分 类 号：R735.2[医药卫生—肿瘤]