戊脉安对缺血再灌注大鼠胃粘膜的保护作用及机制研究  

Protective effect of verapamil on induced gastric mucosal injury in rats by ischemiareperfusion

作　　者：赵文[1] 许继田[1] 李蕾[1] 刘建中[1] 姚运纬[1] 伍忍[1] 

机构地区：[1]河南医科大学生理学教研室

出　　处：《河南医科大学学报》1997年第4期21-23,共3页Journal of Henan Medical University

基　　金：河南省卫生厅资助

摘　　要：利用缺血再灌注方法造成大鼠胃粘膜的损伤模型，观察戊脉安对胃粘膜的保护作用。结果表明：戊脉安无论是胃内给药还是肌内注射，均能明显地降低胃粘膜损伤，起到保护作用。其作用机制可能与降低再灌注期胃组织中丙二醛的含量，减少胃酸分泌有关。he protective effect of verapamil,a calcium channel blocker,on gastric membrane injury in rats induced by ischemiareperfusion and the possible mechanisms were investigated.The results showed that the treatment with verapamil before ischemia produced significant protection against gastric injury in rats induced by ischemiareperfusion.The mechanisms of protection may be related to the decrease of MDA in gastric tissue and the gastric acid output by verapamil.

关 键 词：戊脉安 缺血再灌注 丙二醛 胃酸分泌 

分 类 号：R333.2[医药卫生—人体生理学] R972[医药卫生—基础医学]