N-取代芳酰氨基-5-氟代苯基-2-呋喃甲酰硫脲的合成与生物活性测定  

Synthesis and Biological Activities of N-(Substituted aroylamino)-5-(fluorophenyl)-2-furoyl Thioureas

作　　者：薛思佳[1] 卞王东[1] 柴安[1] 吁松瑞[1] 

机构地区：[1]上海师范大学生命与环境科学学院化学系,上海200234

出　　处：《有机化学》2008年第5期865-869,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20672073);上海市重点学科建设(No.T0402)资助项目

摘　　要：从5-氟代苯基-2-呋喃甲酸出发,经酰化、异硫氰酸酯化,再与取代芳酰肼反应合成了20个未见文献报道的N-取代芳酰氨基-5-氟代苯基-2-呋喃甲酰硫脲.目标产物的结构经IR,1H NMR和元素分析测定确证.初步生物活性测试表明,部分化合物对棉花枯萎病、黄瓜灰霉病、苹果轮纹病和棉花炭疽病有较好的选择性杀菌活性;部分目标化合物有较好的除草活性.Twenty new N-（substituted aroylamino）-5-（fluorophenyl）-2-furoyl thioureas were synthesized and their structures were determined by ^1H NMR, IR spectra and elemental analysis. The preliminary biological activity tests show that some of these target compounds have good fungicidal activities and some have good herbicidal activities.

关 键 词：取代芳酰肼 5-氟代苯基-2-呋喃甲酰硫脲 合成 生物活性 

分 类 号：TQ450.1[化学工程—农药化工]