含1,2,4-三唑杂环的新型Strobilurins衍生物的合成及杀菌活性  

Synthesis and Fungicidal Activities of Novel Analogues of Strobilurins Containing 1,2,4-Triazol Moiety

作　　者：赵培亮[1] 章博[1] 王亚洲[1] 杨光富 

机构地区：[1]华中师范大学化学学院农药与化学生物学教育部重点实验室,武汉430079

出　　处：《有机化学》2008年第5期875-880,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20432010;20476036;20172017);教育部跨世纪优秀人才资助计划;教育部重点科技项目;湖北省优秀创新群体(No.2004ABC002)资助项目

摘　　要：为了寻找新的高活性先导化合物,设计合成了14个未见文献报道的Strobilurins类衍生物,结构经MS,1H NMR,元素分析确认.并用X-ray单晶衍射测定了(E)-3-甲氧基-2-[(5-甲基-4-邻溴代苯亚甲基亚胺基-1,2,4-三唑)-3-硫亚甲基]-苯基丙烯酸甲酯(5i)的晶体结构,证实了分子中的两个C=C均为E-式构型.初步生物活性测试结果表明,在实验浓度下部分化合物具有一定的杀菌活性.In order to find highly active lead compounds, fourteen novel derivatives of strobilurins were designed and synthesized. Their structures were characterized by MS, ^1H NMR spectra and elemental analysis. The single crystal structure of compound 5i was determined by X-ray diffraction analysis, which revealed that the two carbon-carbon double bonds in the molecule were of E,E-configurations. The preliminary bioassay showed that some of them exhibited certain fungicidal activities.

关 键 词：STROBILURINS 杀菌活性 晶体结构 

分 类 号：TQ455.4[化学工程—农药化工]