新型双缩硫代对称二氨基脲类衍生物的合成和生物活性测试  

Synthesis and Biological Activities of Novel Thiocarbohydrazone Derivatives

作　　者：孙亚栋[1] 解正峰[1] 刘方明[2] 陈家胜[1] 

机构地区：[1]新疆大学化学与化工学院,乌鲁木齐830046 [2]杭州师范学院化学系,杭州310012

出　　处：《有机化学》2008年第5期889-893,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20562011);新疆大学青年教师科研启动基金资助项目

摘　　要：探讨了硫代对称二氨基脲与10种含三唑基或苯并三唑基的取代苯乙酮的缩合反应,制得10种新的1,5-二取代苯乙酮双缩硫代对称二氨基脲类化合物,产物经IR,1H NMR,13C NMR和MS及元素分析确证.并对这些化合物的抗真菌和抗病毒活性进行了测试.The condensation reaction of thiocarbohydrazide with ten substituted acetophenones containing triazole or benzotriazole moiety is described. Ten new N^1,N^5-bis[α-（1,2,3-trizaol- 1-ylmethyl）-（un）substituted benzylidene]thiacarbohydrazide derivatives have been synthesized. Their structures were confirmed by elemental analysis, IR, ^1H NMR, ^13C NMR and MS spectra. The antifungal and antivirus activities of the new compounds have been tested.

关 键 词：三唑 苯并三唑 双缩硫代对称二氨基脲 

分 类 号：O626[理学—有机化学]