无溶剂无催化剂条件下芳香醛与3-甲基异噁唑-5-酮的缩合反应  

Condensation Reactions of Aromatic Aldehydes with 3-Methyl-4,5-dihydroisoxazol-5-one without Solvent and Catalyst

作　　者：张英群[1] 王春[1] 张美月[1] 崔朋雷[1] 李越敏[1] 周欣[1] 李敬慈[1] 

机构地区：[1]河北农业大学理学院,保定071001

出　　处：《有机化学》2008年第5期914-917,共4页Chinese Journal of Organic Chemistry

基　　金：河北省自然科学基金(No.299158);河北农业大学非生命学科和新兴学科科研发展基金资助项目

摘　　要：在无溶剂无催化剂条件下,芳香醛与3-甲基异噁唑-5-酮经室温研磨和固相加热发生缩合反应得到了系列3-甲基-4-芳亚烃基异噁唑-5-酮.产物的结构经1H NMR,IR,MS和元素分析确证.A series of 4-arylmethylidene-3-methyl-4,5-dihydroisoxazol-5-one derivatives were synthesized by the condensation reactions of aromatic aldehydes with 3-methyl-4,5-dihydroisoxazol-5-one via room temperature grinding or heating under solvent-free conditions without any catalyst. The products were identified by ^1H NMR, IR, MS spectra and elemental analysis.

关 键 词：3-甲基异噁唑-5-酮 3-甲基-4-芳亚烃基异噁唑-5-酮 芳香醛 乙酰乙酸乙酯 盐酸羟胺 缩合 无溶剂 

分 类 号：O643.32[理学—物理化学]