玉竹抗衰老有效部位的药效筛选  

Experimental Study on the Anti-aging Active Components in Rhizoma Polygonati Odorati

作　　者：李盛青[1] 徐大量[1] 林辉[1] 

机构地区：[1]广州中医药大学中药学院,广州510006

出　　处：《中药新药与临床药理》2008年第3期177-180,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的探讨玉竹抗衰老作用机制和玉竹抗衰老的有效部位。方法连续灌服玉竹的系统溶剂提取物56 d,观察其对D-半乳糖所致的亚急性衰老小鼠的记忆力、学习力、耐力以及对胸腺、脾脏、睾丸指数和血浆SOD活力、肝脏组织中MDA含量的影响。结果水提部位有改善衰老小鼠记忆力、学习力的趋势,能显著增强耐力,对抗胸腺和睾丸的萎缩,提高血浆SOD活力,降低肝组织MDA含量。结论玉竹水提部位可能是其抗衰老的有效部位,其作用机制可能与提高免疫功能、预防性腺萎缩、抗氧化、清除自由基和增强耐力有关。Objective To explore the anti -aging mechanisms of Rhizoma Polygonati Odorati （RPO） and its anti -aging active components. Methods After drenching extracts of RPO for 56 days, the behavioral indexes of memory, learning and tolerance, changes of immune organs of spleen and thymus gland, testis index, plasma superoxide dismutase （SOD） activity, hepatic malondialdehyde （MDA） content were observed in D - galactose - induced subacute senile mice model. Results Aqueous extract shows a trend of improving the memory and learning abilities, and can increase the tolerance of aging - model mice, prevent the atrophy of thymus gland and testis, enhance the activity of SOD and reduce the content of MDA. Conclusion Aqueous extract of RPO may be the anti - aging active components in RPO, and its mechanism may be concerned with the increase of immune function, prevention of the atrophy of genitical glands, counteraction of oxidation, clearance of free radicals and prevention of senile dementia.

关 键 词：玉竹 亚急性衰老 D-半乳糖 超氧化物歧化酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]