冠心病患者动脉弹性指数的特点研究  

Characteristics of artery elasticity indexes in patients with coronary artery disease

作　　者：孟晓敏[1] 孙宁玲[2] 喜杨[2] 刘喜荣[2] 

机构地区：[1]河北保定市第一中医院心内科,071000 [2]北京大学人民医院心内科,100044

出　　处：《国际心血管病杂志》2008年第3期181-183,共3页International Journal of Cardiovascular Disease

摘　　要：目的:探讨冠心病患者周围动脉弹性指数的变化特点。方法:通过冠状动脉造影入选106例冠心病患者和84例冠脉造影结果正常者。测定其大动脉弹性指数(C1)和小动脉弹性指数(C2),比较不同患者间C1和C2的差异,观察动脉弹性指数与心血管危险因素(年龄、高血压史、糖尿病史、脉压等)及冠状动脉病变支数的关系。结果:(1)冠心病患者的C1、C2明显低于正常者;(2)冠心病合并高血压患者的C1、C2明显低于血压正常的冠心病患者;而合并糖尿病患者的C2明显低于非糖尿病患者;(3)随着冠脉病变支数的增加及脉压的增大,C1、C2均显著减低;(4)多元逐步回归分析显示,年龄、脉压、病变支数是影响C1、C2的危险因素,而糖尿病是影响C2的危险因素。结论:动脉弹性指数(C1、C2)在一定程度上可以作为判断冠心病患者动脉功能的重要无创性指标。Objective： To study the changes of peripherial artery elasticity indexes in patients with coronary artery disease （CAD）. Methods：After percutaneous transluminal coronary angiography, a total of 106 patients with CAD and 84 normal subjects were recruited. Large artery elasticity index （C1） and small artery elasticity index （C2） of these subjects were measured. The relationship between cardiovascular risk factors （age, hypertension and diabetes history, pulse pressure）, the number of diseased coronary artery and artery elasticity was analysed. Results：（1） C1 and C2 in patients with CAD were lower significantly than controls. （2） C1 and C2 in patients combined with hypertension were lower significantly than that in normotensive patients. C2 in patients combined with diabetes were lower significantly than that in nondiabetic patients. （3） With the numbers of diseased coronary artery and pulse pressure increasing, C1 and C2 in patients decreased significantly. （4） The multiple regression analysis indicated that age, pulse pressure and the number of diseased coronary artery were risk factors which affected C1. And diabetes mellitus was risk factor, which affected C2 except for above factors. Conclusion：Artery elasticity indexes （C1 and C2） might partly be the important non-invasive indexes, which could be used to evaluate the artery function of patients with CAD.

关 键 词：冠心病 动脉弹性指数 高血压 糖尿病 脉压 

分 类 号：R541.4[医药卫生—心血管疾病]