统一多系统萎缩评估量表与病程的相关性分析  

Correlation analysis between Unified Multiple System Atrophy Rating Scale and duration of multiple system atrophy

作　　者：顾卫红[1] 王国相[1] 杨斯柳[1] 王康[1] 段晓慧[1] 

机构地区：[1]卫生部中日友好医院神经内科,北京100029

出　　处：《中华神经科杂志》2008年第5期332-334,共3页Chinese Journal of Neurology

基　　金：卫生部临床学科重点项目（2004-2006）

摘　　要：目的研究多系统萎缩（MSA）患者的临床评估量表与病程的相关性。方法总结122例符合Gilman诊断标准的多系统萎缩患者的临床资料，采用统一多系统萎缩评估量表（UMSARS）进行评估，并应用Spearman等级相关分析方法进行量表评分与病程的相关性统计学分析。结果122例多系统萎缩患者男女比例为1．7：1，病程（2．8±1．6）年；其中50例（41％）符合“可能的”MSA诊断标准，72例（59％）符合“很可能的”MSA诊断标准；MSA—P型35例占29％，MSA．C型73例占60％，MSA-P＋C叠加型5例占4％，MSA-A型9例占7％。统计学分析显示UMSARS总分、UMSARS-Ⅰ和UMSARS-Ⅱ评分均与病程呈正相关关系，Spearman等级相关系数分别为0．368、0．266和0．392，均P〈0．01；校正的等级相关系数分别为0．360、0．257和0．385，均P〈0．01。结论MSA临床表现复杂多样，分型中应包括MSA—P＋C叠加型。UMSARS评分可较好地反映MSA的病程进展，对于研究MSA的临床特征和病程具有重要意义。Objective To study the correlation between clinical rating scale and the duration of multiple system atrophy. Methods One hundred and twenty-two MSA cases fulfilling Gilman diagnostic criteria were recruited. Unified Multiple System Atrophy Rating Scale （UMSARS） was applied to assess the degree of the patients＇ disability. For analyzing the correlation between the UMSARS scores and the duration of the disease, the Spearman＇ s rank correlation coefficients were calculated. Results Among 122 MSA cases, male： female ratio was 1.7 ： 1 ; disease duration lasted （ 2. 8± 1.6 ） years ; possible MSA accounted for 50 cases（41% ）, probable MSA 72 cases（59% ） ;MSA-P 35 cases （29%） ; MSA-C 73 cases（60% ）, MSA-P ＋C 5 cases（4% ）, MSA-A 9 cases（7% ）. The scores of UMSARS, UMSARS- Ⅰ and UMSARS- Ⅱ were found positively correlating with the disease duration. The Spearman＇ s rank correlation coefficients were 0. 368,0. 266 and 0. 392 respectively, all P 〈 0. 01 ; the adjusted Spearman＇ s rank correlation coefficients were 0. 360, 0. 257 and 0. 385 respectively, all P 〈 0. 01. Conclusions MSA has complex clinical manifestations, which should include MSA-P ＋ C subtype. UMSARS is a reliable scale to mirror the progression of MSA, which is useful to study the clinical features and disease duration of MSA.

关 键 词：多系统萎缩 疾病严重程度指数 量表 病程进展 

分 类 号：R686[医药卫生—骨科学]