普罗雌烯中间体雌二醇3-正丙基醚的合成方法改进研究  

Modified Synthesis of Oestradiol 3-Propyl Ether—the Intermediate Compound of Promestriene

作　　者：崔建彤 逯宝娣[2] 

机构地区：[1]山西亚宝药业集团股份有限公司,山西芮城044600 [2]太原科技大学化学与生物工程学院,山西太原030021

出　　处：《山西大学学报（自然科学版）》2008年第2期221-222,共2页Journal of Shanxi University(Natural Science Edition)

摘　　要：对普罗雌烯中间体雌二醇3-正丙基醚的合成方法进行了改进,采用氢氧化钠及正四丁基硫酸氢铵作为相转移催化剂代替乙醇钠,在较温和条件下合成了雌二醇3-正丙基醚,然后在氢化钠存在下与硫酸二甲酯反应制备普罗雌烯.以雌二醇计,摩尔收率为78.1%.The intermediate compound of promestriene,oestradiol 3-propyl ether,was synthesized under mild condition by using sodium hydroxide and tetrabutyl ammonium hydrosulfate as phase transfer catalyst in place of sodium ethoxide. Promestriene was prepared successively from the reaction of oestradiol 3-propyl ether with dimethyl sulfate in the presence of sodium hydride with the molar yield of 78.1%. The results showed that the process used in this paper was simple and in high yield, and it was suitable for industrialization.

关 键 词：普罗雌烯 雌二醇 相转移催化法 

分 类 号：O621.3[理学—有机化学]