慢性乙肝与急性戊肝重叠感染的临床特点  

The clinical features of chronic hepatitis B virus infected patients superinfected with hepatitis E virus

作　　者：卫嬛[1] 高文军[1] 冯健华[1] 蔡常辉[1] 高齐明[1] 郭炜[1] 张倩华[1] 蔡仲华[1] 

机构地区：[1]广东省中山市人民医院,中山528403

出　　处：《中国实用医刊》2008年第2期32-33,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨慢性乙肝重叠戊型肝炎病毒（HEV）急性感染的临床特点。方法将78例慢性乙肝重叠HEV感染（简称戊乙肝）与单纯HEV感染进行对照研究。结果78例戊型肝炎均为急性起病。平均年龄（46±17）岁，其中戊乙肝35例，单纯戊肝43例，男女比例2．39：1。戊乙肝组总胆红素（256±141μmol／L），肝性脑病发生率（14．3％），重型肝炎发生率（40．0％），明显高于单纯戊肝（P〈0．05）。结论慢性乙肝重叠HEV急性感染易导致慢性乙型肝炎活动。易发生重型肝炎，病死率高，预后差。Objective To explore the clinical features of patients with chronic hepatitis B virus（HBV） superinfected with hepatitis E virus （HEV）. Methods The clinical characteristic of the patients with HBV and HEV superinfection were compared with those simple HEV infection, Results Totally 78 hepatitis E cases were all acute attacked with an average of （46 ± 17） years old and the ratio of male to female was 2.39： 1. The 35 cases of them were HBV/HEV superinfection ,the other 43 cases were the simple hepatitis E. In the HBV/HEV superinfection group the level of total serum bilirubin was （256±141 ）μmol/L,the hepatic encephalopathy rate was 14.3% ,the severe hepatitis rate was 40.0%, obviously more than that in the simple hepatitis E group（ P 〈0.05）. Conclusion Superinfection of HBV and HEV can cause chronic and more severe hepatitis, the poorer prognosis.

关 键 词：乙型肝炎病毒 戊型肝炎病毒 重叠感染 

分 类 号：R512.62[医药卫生—内科学] R532.210.1[医药卫生—临床医学]