双波长法测定马来酸氨氯地平的含量  

Determination of Amlodipine Maleate in Tablet by Differential Spectrophotometry

作　　者：夏都灵[1] 李雪芳[1] 

机构地区：[1]电子科技大学微电子与固体电子学院,成都610054

出　　处：《电子科技大学学报》2008年第3期464-465,473,共3页Journal of University of Electronic Science and Technology of China

摘　　要：为了建立一种简便、快速、价廉的马来酸氨氯地平片的含量测定方法,该文采用差示分光光度法(425nm和365nm为测定双波长)测定马来酸氨氯地平片剂中马来酸氨氯地平的含量,线性区间为5.0～50.0μg/ml,回收率为99.92%,RSD为0.67%。该方法既能有效消除辅料混浊溶液的干扰,又简便、快速、准确。Amlodipine maleate is a new kind of medicine for hypertensive disease. This article mainly studies the conditions of quantitatively measuring arnlodipine maleate of tablet. The double-wave, 365 nm and 425 nm, spectrophotometry was used for determining the content of the arnlodipine maleate tablet to eliminate interference ofexcipient. The absorbanee is well linear with concentration between 5.0 μg/ml and 50.0 μg/ml, and the linear equation of differential spectrophotometry is △A =0.01149C＋0.003 （r=0.9994）, the coefficient of recovery is 99.92%, and RSD is 0.67%.

关 键 词：马来酸氨氯地平 马来酸氨氯地平片 差示分光光度法 混浊溶液 

分 类 号：R927.1[医药卫生—药学]