肝病瘀血舌象患者与血瘀证各组ET/NO的临床实验研究  

Study on NO/ET in Patients with Hepatopathy TBS

作　　者：武哲丽[1] 陈群[1] 徐志伟[1] 莫传伟[1] 刘梅[1] 修宗昌[1] 王剑[1] 

机构地区：[1]广州中医药大学,广东广州510006

出　　处：《四川中医》2008年第5期4-5,共2页Journal of Sichuan of Traditional Chinese Medicine

基　　金：国家自然科学基金项目资助课题(NO.30472122);国家"十一五"科技支撑计划课题(NO.2006BAI08B01-3);973计划课题(NO.2005CB523502)

摘　　要：目的:从分子水平探讨瘀血舌象肝病患者不同血瘀证及其形成的病理机制。方法:采用前瞻性研究的方法进行肝病瘀血舌患者血液ET、NO的测定。结果:肝病瘀血舌不同血瘀证组与正常组的ET、NO、NO/ET的比较表明:肝病瘀血舌血瘀证各组的ET、NO、NO/ET显著增高(P<0.05或P<0.01)。肝病瘀血舌不同血瘀证组与气虚血瘀组比较结果显示:肝瘀痰阻和气滞血瘀的ET、NO与气虚血瘀组比较有显著差异(P<0.05);瘀血舌不同肝病组与正常组的ET、NO、NO/ET的比较表明:肝病各组的ET、NO、NO/ET显示增高(P<0.01)。结论:瘀血舌不同肝病各组及血瘀证组的ET、NO、NO/ET显著增高,说明NO与ET水平的升高与肝细胞受损有关。肝瘀痰阻和气滞血瘀的ET、NO与气虚血瘀组比较有显著性差异,说明可能与肝病的肝瘀痰阻型造成的血瘀程度要比其他型更严重有关,因此ET、NO、NO/ET可能是反映肝病瘀血舌患者的血瘀程度的指标。Objective： To explore the pathology mechanism of hepatopathy tongue of blood stasis （TBS） from a molecular level. Methods： ET and NO in the blood of hepatopathy TBS were determined through prospective studies. Results： ET, NO and NO/ET in the blood of all patients in hepatopathy TBS groups were much higher than that of the patients in normal group （ P 〈 0.05 or P 〈 0.01 ）. There was significant difference between ET, NO and NO/ET in the blood of patients in group with Qi .deficiency and Blood stasis syndrome （QDBSS group] and that of group with phlegm and blood stasis syndrome （PBSS group] and that of group Qi and blood stasis syndrome （QBSS group） （ P 〈 0.05）. ET, NO and NO/ET in the blood of patients in Group hepatopathy TBS were much higher than those in normal group （ P 〈 0.01 ）. Conclusion： ET, NO and NO/ET in the bided of patients in hepatopathy TBS group and BSS group are significantly higher than those of the normal group. It indicates that there is certain connection between the increase of NO and ET and the injury of liver cells. The significant increase of ET, NO and NO/ET in PBSS group possibly results from the much serious blood stasis. ET, NO and NO/ET are possibly the indices of blood stasis degree of bepatopathy TBS.

关 键 词：肝病 瘀血舌象 血瘀证 ET/NO 实验研究 

分 类 号：R255.7[医药卫生—中医内科学]