增殖细胞核抗原与慢性萎缩性胃炎中医证型关系的研究  

Research on the Relationship between PCNA and the TCM Differentiation Typing of CAG

作　　者：孙良华[1] 李群[1] 王树庆[1] 马传香[1] 张媛媛[1] 

机构地区：[1]潍坊医学院附属医院,山东潍坊261031

出　　处：《四川中医》2008年第5期8-10,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：山东省中医管理局科研基金项目(编号:2005-237)

摘　　要：目的:研究增殖细胞核抗原(PCNA)与慢性萎缩性胃炎(CAG)中医证型的关系,探讨中医证型的实质,为临床治疗提供理论依据。方法:经胃镜及病理组织学检查确诊的200例CAG患者,进行了中医辨证分型,采用免疫组化法检测不同证型CAG胃黏膜PCNA的表达水平。结果:脾胃虚弱证72例,肝胃不和证43例,脾虚气滞证32例,胃阴不足证24例,脾胃湿热证14例,胃络瘀阻证5例。肝胃不和证PCNA的表达水平与脾胃虚弱证、脾虚气滞证、胃阴不足证之间有显著性差异(P<0.01)。结论:CAG以脾胃虚弱证和肝胃不和证居多,PCNA的高表达可能是肝胃不和证的诊断依据。Objective： To research the relationship between proliferation cell nuclear antigen （PCNA） of the gastric mueosa and the TCM differentiation typing of chronic atrophic gastritis （CAG）, and to explore the standards of TCM differentiation typing so as to provide theoretical reference for clinical treatment. Methods： A total of 200 CAG patients were chosen through with gastrofiberscope and pathological check, and were differentially classified. Immunohistochemistry was used to detect the expression level of PCNA in different TCM types of CAG patients. Results ： There are 72 eases of deficiency in the spleen and stomach, 43 eases of disharmony between liver and stomach, 32 eases of Qi stagnation and deficiency in the spleen, 24 eases of Yin deficiency in the stomach, 14 eases of wet and heat in spleen and stomach, and 5 eases of gastric silt resistance. Of the total, the difference of PCNA expression level between disharmony between liver and stomach and the other three types are prominent （ P〈 0.01）. Conclusion： Deficiency in the spleen and stomach and disharmony between the liver and stomach were the most common types in CAG eases. The high expression of PCNA might be the diagnosis evidence of disharmony between the liver and stomach.

关 键 词：慢性萎缩性胃炎 中医证型 免疫组织化学 增殖细胞核抗原 

分 类 号：R256.33[医药卫生—中医内科学]