热休克蛋白70融合肿瘤抗原基因的DNA疫苗研究进展  

Research progress on the DNA vaccine of HSP70 fused with tumor antigen gene

作　　者：宗金宝[1] 许雪梅[1] 

机构地区：[1]中国医学科学院基础医学研究所北京协和医学院基础学院,北京100005

出　　处：《基础医学与临床》2008年第5期512-515,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(30271355)

摘　　要：在抗肿瘤免疫治疗中,已经发展了多种形式的热休克蛋白70(HSP70)相关治疗性疫苗,这些疫苗主要包括蛋白疫苗、肽疫苗、细胞疫苗及DNA疫苗等,其中HSP70融合DNA疫苗凭借其自身的优势引起人们的关注。它不但可诱导高效、持久的抗肿瘤免疫应答,而且可以维持免疫记忆。本文就HSP70在肿瘤治疗性DNA疫苗中的作用和应用作一综述。A variety of heat shock protein 70 （HSP70） -associated therapeutic vaccines including protein vaccine, peptide vaccine, tumor cell vaccine and DNA vaccine, have been developed and applied in anti-tumor immunotherapy, in which HSP70-fused DNA vaccine attracts our attention with its superiority. It not only induces consistent anti-tumor immune response but also helps sustain immune memory. In this article we reviewed the function and application of HSP70 in the therapeutic tumor DNA vaccine.

关 键 词：热休克蛋白70 DNA疫苗 

分 类 号：R392[医药卫生—免疫学]