Skp2、p27^(kip1)在尖锐湿疣组织中的表达  

Expression of Skp2 and p27^(kip1) in condyloma acuminatum

作　　者：龚锦[1] 涂亚庭[1] 林能兴[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤性病科,武汉430022

出　　处：《中国麻风皮肤病杂志》2008年第5期351-352,共2页China Journal of Leprosy and Skin Diseases

摘　　要：目的:研究Skp2(S期激酶相关蛋白2)和p27蛋白在尖锐湿疣组织中的表达。方法:采用免疫组织化学S-P法和图像分析系统检测Skp2和p27kip1两种蛋白在20例尖锐湿疣组织、12例正常包皮中的表达。结果:(1)Skp2蛋白在尖锐湿疣组织中的表达率显著高于正常包皮组织(P<0.05)。(2)p27kip1在尖锐湿疣组织中表达率较正常包皮组织中的表达率明显下降(P<0.05)。(3)尖锐湿疣组织中Skp2与p27kip1表达呈负相关(P<0.05)。结论:尖锐湿疣患者Skp2和p27kip1的表达异常导致细胞周期失控并促使细胞异常增殖。Objective： To investigate the expression of S-phase kinase-associated protein2 （Skp2） and p27^kip1 in condyloma acuminatum （CA）. Methods： Immuno-histochemical S-P method and color pathological image computer analysis system were applied to detect the expressions of Skp2 and p27^kip1 in 12 normal foreskin and 20 patients with CA. Results： The expression of Skp2 protein was significantly higher in CA than in normal foreskin tissue （ P 〈 0.05）. The expression of p27^kip1 was significantly lower in CA than in normal foreskin tissue （ P 〈 0.05）. The expression of p27^kip1 was negatively correlated to Skp2 （ P 〈 0.05）. Condusion： The abnormal expression of Skp2 and p27^kip1 in CA may leads to a dysfunction of cell- generation cycle, which can promote the cell proliferation.

关 键 词：尖锐湿疣 S期激酶相关蛋白2 P27^KIP1 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]