2型糖尿病患者内脏素水平与胰岛素抵抗、胰岛β细胞功能之间的关系  

Study on the relationship between visfatin and insulin resistance,beta-cell function in type 2 diabetes mellitus

作　　者：刘军[1] 查英[1] 王芳[1] 陈灶萍[1] 徐炯[1] 盛励[1] 廖晓寰[2] 郭瑜琳[3] 

机构地区：[1]复旦大学附属上海市第五人民医院内分泌科,上海200240 [2]复旦大学附属上海市第五人民医院免疫室,上海200240 [3]复旦大学附属上海市第五人民医院血管超声室,上海200240

出　　处：《临床内科杂志》2008年第5期333-335,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨2型糖尿病患者内脏素水平变化及与胰岛抵抗和胰岛β细胞功能之间的关系。方法检测了2型糖尿病患者95例和正常对照组54例内脏素、血脂、血糖和空腹胰岛素(FINS)水平,并评价了颈总动脉内膜中层厚度(IMT)。采用稳态模式(HOMA)评价胰岛素抵抗和胰岛β细胞功能。结果2型糖尿病组胰岛素抵抗指数(HOMA-IR)、颈动脉IMT和内脏素水平高于对照组,胰岛β细胞功能指数(HOMA-β)水平低于对照组(P<0.05)。Spearman相关性分析显示,内脏素与空腹血糖(r=0.496,P=0.000)和HOMA-IR(r=-0.380,P=0.000)呈正相关;与HOMA-β(r=-0.355,P=0.000)呈负相关。多元逐步回归分析显示,内脏素与空腹血糖呈独立正相关(P=0.000)。结论2型糖尿病患者内脏素水平升高,内脏素可能与胰岛素抵抗和胰岛β细胞功能损害有一定相关性。Objective To investigate the relevance of visfatin to insulin resistance and the betacell function in type 2 diabetes mellitus. Methods The plasma visfatin, serum lipids, serum glucose and fasting insulin（FINS） were measured in 95 type 2 diabetes（T2DM） and 54 normal control subjects（NC）. The intima-media thickness（IMT） of common carotid arteries were detected by high resolution ultrasound. Homeostasis model assessment（HOMA） was applied to assess the status of insulin resistance and beta-cell function. Results The levels of visfatin,HOMA-IR and IMT of common carotid arteries were significantly elevated and HOMA-β was lower in T2DM group compared with NC group. In all subjects, spearman correlation analysis showed that visfatin was positively correlated to FBG（ r = 0.496 ,P = 0.000）, HOMA-IR （ r = - 0.380, P = 0.000） and negatively correlated to HOMA-β （ r = - 0. 355, P = 0.000）. Multiple stepwise regression analysis showed visfatin were the independent risk factors affected the FBG. Conclusions There was increased plasma visfatin in type 2 diabetes mellitus. Hypervisfatimnia probably related to insulin resistance and beta-cell disfunction.

关 键 词：内脏素 糖尿病 2型 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]