中药预防胆囊胆固醇结石实验研究  

Experimental Research on Prevention of Bilirubin Gallstone with Traditional Chinese Medicine Therapy

作　　者：刘禹翔[1] 李健[1] 黄彬[1] 张竞超[1] 郭绍举[1] 

机构地区：[1]广东省深圳市中医院,深圳518033

出　　处：《中国中医急症》2008年第5期666-667,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：广东省深圳市医学重点专科及科技计划(No.200204236)

摘　　要：目的观察防石胶囊预防胆固醇性胆囊结石的作用。方法将60只豚鼠随机分为四组,空白组饲喂普通饲料,模型组饲喂胆固醇结石诱石饲料,UDCA(熊去氧胆酸)组饲喂胆固醇结石诱石饲料加UDCA,中药组饲喂胆固醇结石诱石饲料加防石胶囊;计算胆囊结石发生率及胆汁中钙离子浓度。结果胆囊结石发生率由高至低呈模型组、UDCA组、中药组、空白组,中药组胆汁中钙离子浓度与模型组有明显差异。结论防石胶囊有助于防止胆囊结石的复发,其机制可能与其降低胆汁中钙离子浓度有关。Objective：To observe the effect of Fangshi capsule to prevent bilirubin gallstone.Method：60 cavia cobayaes were divided into 4 groups.The blank group was fed with ordinary bait vessel,the model group was fed with bait vessel of cholesterol calculus derivation,the UDCA（Ursodeoxycholic acid） therapy group was fed with bait vessel of cholesterol calculus derivation and UDCA,the TCM（traditional Chinese medicine） therapy group was fed with bait vessel of cholesterol calculus derivation and Fangshi capsule.The incidence rate of cholecystolithiasis and the calcium ionic concentration in bile were detected.Result：The incidence rate of cholecystolithiasis arranged from high to low was：the model group 〉the UDCA therapy group 〉the blank group.The calcium ionic concentration in bile of TCM therapy group was obviously different with that of model group.Conclusion：the Fangshi capsule can prevent the recidivation of cholecystolithiasis.The mechanism perhaps is concerned with the therapy function of degrade the calcium ionic concentration.

关 键 词：胆囊结石 防石胶囊 

分 类 号：R285.5[医药卫生—中药学]